心脏中的p38丝裂原活化蛋白激酶
p38 MAP kinases in the heart.
作者信息
Yokota Tomohiro, Wang Yibin
机构信息
Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Physiology and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Physiology and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
出版信息
Gene. 2016 Jan 10;575(2 Pt 2):369-376. doi: 10.1016/j.gene.2015.09.030. Epub 2015 Sep 20.
p38 kinases are members of the mitogen-activated protein kinases (MAPK) with established contribution to a wide range of signaling pathways and different biological processes. The prototypic p38 MAPK, p38α was originally identified as an essential signaling kinase for inflammatory cytokine production Extensive studies have now revealed that p38s have critical roles in many different tissues far beyond immune regulation and inflammatory responses. In this review, we will focus on the structure and molecular biology of p38s, and their specific roles in heart, especially regarding myocyte proliferation, apoptosis, and hypertrophic responses.
p38激酶是丝裂原活化蛋白激酶（MAPK）家族的成员，对多种信号通路和不同的生物学过程有明确贡献。典型的p38 MAPK，即p38α最初被鉴定为炎症细胞因子产生所必需的信号激酶。现在广泛的研究表明，p38激酶在许多不同组织中具有关键作用，远远超出免疫调节和炎症反应。在本综述中，我们将重点关注p38激酶的结构和分子生物学，以及它们在心脏中的特定作用，特别是在心肌细胞增殖、凋亡和肥大反应方面。
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