诱导型一氧化氮合酶基因多态性与癌症风险的关联性缺失：一项系统评价与Meta分析
Lack of association of the iNOS gene polymorphism with risk of cancer: a systematic review and Meta-Analysis.
作者信息
Jiao Jinghua, Wu Jingyang, Huang Desheng, Liu Lei
机构信息
Department of Anesthesiology, Central Hospital, Shenyang Medical College. Shenyang, 110024, China.
Department of Ophthalmology, The First Affiliated Hospital, China Medical University. Shenyang, 110001, China.
出版信息
Sci Rep. 2015 Sep 22;5:9889. doi: 10.1038/srep09889.
In order to investigate the association between the iNOS gene polymorphisms and susceptibility to cancer, a search of English papers was done using Pubmed, the Cochrane Library, Embase, ISI Web of Science, Google (scholar) database, and all Chinese reports were conducted using CBMDisc, Chongqing VIP database, and CNKI database. A total of eight studies were included in this meta-analysis including 1,920 cases and 2,373 controls. The results indicated that the polymorphisms in iNOS gene (C150T(Ser(608) Leu) polymorphism and polymorphic (CCTTT)n repeats) had no association with cancer risk for all genetic models. This meta-analysis suggested that the polymorphisms in the iNOS gene were not associated with cancer risk.
为了研究诱导型一氧化氮合酶（iNOS）基因多态性与癌症易感性之间的关联，我们使用PubMed、考克兰图书馆、Embase、科学引文索引（ISI）网络数据库、谷歌（学术）数据库检索了英文文献，并使用中国生物医学文献数据库（CBMDisc）、重庆维普数据库和中国知网数据库检索了所有中文报告。本荟萃分析共纳入八项研究，包括1920例病例和2373例对照。结果表明，iNOS基因多态性（C150T（Ser（608）Leu）多态性和多态性（CCTTT）n重复序列）在所有遗传模型中均与癌症风险无关。本荟萃分析表明，iNOS基因多态性与癌症风险无关。
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