Xie R-H, Liu Y-J, Retnakaran R, MacFarlane A J, Hamilton J, Smith G, Walker M C, Wen S W
Dean's office, School of Nursing, Hunan University of Medicine, Huaihua, China.
McLaughlin Center for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada.
Int J Obes (Lond). 2016 Jan;40(1):1-9. doi: 10.1038/ijo.2015.189. Epub 2015 Sep 22.
Prenatal folic acid supplementation or maternal folate sufficiency may protect the offspring from obesity and insulin resistance. This study aims to summarize the findings of association between prenatal folic acid supplementation/maternal folate sufficiency and obesity/insulin resistance in the offspring.
Twelve databases were searched for both published and unpublished work of prenatal folic acid supplementation/maternal folate status up to 1 July 2014. Experimental and observational studies on animals and human beings were included based on the eligibility criteria. There were no limits to the time period and language of publication. The study quality was assessed with a 10-Point Scale for Scientific Methodology.
The search identified 2548 records. Nine animal studies and five human studies satisfied search criteria were included. Five of these nine animal studies showed a protective effect of folic acid. Of the five human studies, one showed a protective effect of folic acid, two showed a harmful effect and two showed uncertain results.
Data from both animal studies and human studies are inconsistent. Future researches with sophisticated designs are needed to demonstrate the potential protective effect of maternal folate on obesity/insulin resistance in the offspring in animal models and human pregnancies.
孕期补充叶酸或母体叶酸充足可能会保护后代免于肥胖和胰岛素抵抗。本研究旨在总结孕期补充叶酸/母体叶酸充足与后代肥胖/胰岛素抵抗之间关联的研究结果。
检索了12个数据库，查找截至2014年7月1日有关孕期补充叶酸/母体叶酸状态的已发表和未发表的研究。根据纳入标准纳入了对动物和人类的实验性和观察性研究。对发表的时间和语言没有限制。采用科学方法10分制评估研究质量。
检索到2548条记录。纳入了9项动物研究和5项符合检索标准的人体研究。这9项动物研究中有5项显示叶酸具有保护作用。在5项人体研究中，1项显示叶酸具有保护作用，2项显示有害作用，2项显示结果不确定。
动物研究和人体研究的数据不一致。需要进行设计更精密的未来研究，以证明母体叶酸对动物模型后代肥胖/胰岛素抵抗以及人类孕期的潜在保护作用。
