肾功能与弥散加权成像：一种在肾功能丧失一半之前诊断肾衰竭的新方法。
Renal function and diffusion-weighted imaging: a new method to diagnose kidney failure before losing half function.
作者信息
Emre Türker, Kiliçkesmez Özgür, Büker Atılay, İnal Berrin Berçik, Doğan Hüseyin, Ecder Tevfik
机构信息
Department of Nephrology, Istanbul Research and Training Hospital, Istanbul, Turkey.
Department of Radyology, Istanbul Research and Training Hospital, Istanbul, Turkey.
出版信息
Radiol Med. 2016 Mar;121(3):163-72. doi: 10.1007/s11547-015-0579-0. Epub 2015 Sep 21.
AIM
To diagnose earlier kidney failure, we investigated renal functions with diffusion-weighted imaging (DWI).
METHODS
We evaluated the DWI of 62 patients with chronic kidney disease (CKD) and compared it with creatinine clearance provided by daily urine collection. The apparent diffusion coefficient (ADC) values were compared with the five stages of CKD.
RESULTS
For each stage of CKD, the ADC values were found to be significantly different (p < 0.01) and allowed the differentiation of stage 1 of the disease from the other stages.
CONCLUSION
Renal ADC values show a significant correlation with the clinical stages of CKD. DWI may detect renal failure prior to a rise in creatinine.
目的
为了更早地诊断肾衰竭，我们采用扩散加权成像（DWI）对肾功能进行了研究。
方法
我们评估了62例慢性肾脏病（CKD）患者的DWI，并将其与每日收集尿液所测得的肌酐清除率进行比较。将表观扩散系数（ADC）值与CKD的五个阶段进行比较。
结果
发现CKD各阶段的ADC值存在显著差异（p < 0.01），且能将疾病的1期与其他阶段区分开来。
结论
肾脏ADC值与CKD的临床分期显著相关。DWI可能在肌酐升高之前检测到肾衰竭。
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