埃塞俄比亚营养不良儿童中疟疾检测与发热及营养不良程度的关系

Detection of malaria in relation to fever and grade of malnutrition among malnourished children in Ethiopia.

作者信息

Khogali M, Zachariah R, Keiluhu A, Van den Brande K, Tayler-Smith K, Ayada L, Jima D, Hinderaker S G, Harries A D

机构信息

Médecins Sans Frontières, Addis Ababa, Ethiopia.

Medical Department (Operational Research Unit/Operations), Médecins Sans Frontières, Operational Centre Brussels, MSF-Luxembourg, Luxembourg.

出版信息

Public Health Action. 2011 Sep 21;1(1):16-8. doi: 10.5588/pha.11.0008.

DOI:10.5588/pha.11.0008

PMID:26392929

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4547182/

Abstract

SETTING

Forty-eight nutritional rehabilitation centres in southern Ethiopia.

OBJECTIVE

To determine 1) the frequency of temperature recording under programme conditions, 2) the proportion of malnourished children with and without fever who had falciparum malaria and 3) the association between malaria and grade of malnutrition.

DESIGN

This was a retrospective analysis of routine programme data.

RESULTS

Of 19 200 malnourished children, 16 716 (mean age 4.4 years, 7412 males) underwent a rapid malaria diagnostic test (Paracheck Pf (®)). Malnutrition was graded as severe (38%), moderate (35%) and mild (27%). Temperature was not recorded in 15 248 (91%) children. Malaria was diagnosed in 57 (28%) children with fever (n = 206) and 122 (10%) children with no fever (n = 1262). The prevalence of falciparum malaria was 9%. Malaria prevalence was significantly associated with grade of malnutrition: Paracheck Pf was positive in respectively 5%, 8% and 10% of children with mild, moderate and severe malnutrition (χ(2) for trend 78, P < 0.001).

CONCLUSIONS

This study shows the value of routine malaria screening in malnourished children, especially those with more severe grades of malnutrition, irrespective of fever. Operational shortcomings are highlighted and ways forward to address these problems are discussed.

摘要

研究背景

埃塞俄比亚南部的48个营养康复中心。

研究目的

确定1）项目条件下体温记录的频率，2）患有和未患发热的营养不良儿童中患恶性疟原虫疟疾的比例，以及3）疟疾与营养不良程度之间的关联。

研究设计

这是一项对常规项目数据的回顾性分析。

研究结果

在19200名营养不良儿童中，16716名（平均年龄4.4岁，7412名男性）接受了快速疟疾诊断检测（Paracheck Pf（®））。营养不良程度分为重度（38%）、中度（35%）和轻度（27%）。15248名（91%）儿童未记录体温。在206名发热儿童中有57名（28%）被诊断为疟疾，在1262名无发热儿童中有122名（10%）被诊断为疟疾。恶性疟原虫疟疾的患病率为9%。疟疾患病率与营养不良程度显著相关：轻度、中度和重度营养不良儿童中Paracheck Pf检测呈阳性的比例分别为5%、8%和10%（趋势χ(2)为78，P < 0.001）。