通过连续的Sonogashira偶联/铜催化氧化环化反应全合成卡洛西辛B。
Total synthesis of calothrixin B via sequential Sonogashira coupling/copper-catalyzed oxidative cyclization.
作者信息
Ramkumar Nagarajan, Nagarajan Rajagopal
机构信息
School of Chemistry, University of Hyderabd, Hyderabad-500046, India.
出版信息
Org Biomol Chem. 2015 Dec 7;13(45):11046-51. doi: 10.1039/c5ob01766a. Epub 2015 Sep 23.
PMID:26395099
Abstract
A total synthesis of the antimalarial indolo[3,2-j]phenanthridine alkaloid calothrixin B is reported. The key intermediate, ketoester 11, was assembled using sequential Sonogashira coupling and intra/intermolecular fashioned copper-catalyzed oxidative cyclization reactions.
摘要
报道了抗疟吲哚并[3,2-j]菲啶生物碱卡洛西辛B的全合成。关键中间体酮酯11是通过连续的Sonogashira偶联和分子内/分子间形式的铜催化氧化环化反应组装而成的。
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