Rak J, Kuśnierczyk H, Strzadała L, Kłosiewicz S, Radzikowski C
Department of Tumor Immunology, Polish Academy of Sciences, Wroclaw.
Arch Immunol Ther Exp (Warsz). 1989;37(3-4):389-97.
On the basis of biological characteristics of murine transplantable mammary adenocarcinoma 16/c, experimental conditions optimal for chemotherapeutic experiments were defined. Sensitivity of primary tumor and lung metastases to the treatment with drugs used in breast cancer therapy: cyclophosphamide, 5-fluorouracil and adriamycin was confirmed. These drugs were significantly more effective in combination than when administered as monotherapy. Antimetastatic but not antitumor effect of 5-fluorouracil could be potentiated by using albumin microspheres as a carrier. Usefulness of the tumor model system in experimental chemotherapy is discussed.
基于小鼠可移植性乳腺腺癌16/c的生物学特性，确定了化疗实验的最佳实验条件。证实了原发性肿瘤和肺转移灶对乳腺癌治疗中使用的药物（环磷酰胺、5-氟尿嘧啶和阿霉素）治疗的敏感性。这些药物联合使用时比单药治疗显著更有效。使用白蛋白微球作为载体可增强5-氟尿嘧啶的抗转移而非抗肿瘤作用。讨论了肿瘤模型系统在实验化疗中的实用性。
