Kowalewski J, Pluta A, Modlińska M, Wasik M, Glapiński T, Nowaczyk M, Bozena Adamczyk M, Górski A
Hematology Clinic, Medical School, Lublin.
Arch Immunol Ther Exp (Warsz). 1989;37(3-4):481-6.
A case of large granular lymphocyte lymphocytosis with neutropenia was studied as evidenced by peripheral lymphocytosis of cells having typical morphology and profound neutropenia. Surface markers analysis revealed that almost all cells were CD8+ and their subpopulation DR+. The cells had strong spontaneous and inducible suppressor functions in vitro. Moreover, their ADCC activity was strong but NK activity very weak.
研究了一例伴有中性粒细胞减少的大颗粒淋巴细胞增多症病例，其外周血淋巴细胞增多，细胞形态典型，且存在严重的中性粒细胞减少。表面标志物分析显示，几乎所有细胞均为CD8+，且其亚群为DR+。这些细胞在体外具有很强的自发和诱导抑制功能。此外，它们的抗体依赖细胞介导的细胞毒性（ADCC）活性很强，但自然杀伤（NK）活性非常弱。
