通过卡宾迁移插入/碳钯化级联反应与甲苯磺酰腙实现钯催化合成并苯并碳环和杂环化合物。
The Pd-catalyzed synthesis of benzofused carbo- and heterocycles through carbene migratory insertion/carbopalladation cascades with tosylhydrazones.
作者信息
Paraja Miguel, Pérez-Aguilar M Carmen, Valdés Carlos
机构信息
Departamento de Química Orgánica e Inorgánica and Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo, c/Julián Clavería 8, Oviedo, 33006, Spain.
出版信息
Chem Commun (Camb). 2015 Nov 21;51(90):16241-3. doi: 10.1039/c5cc06348e.
The Pd-catalyzed reaction between o-iodoallylbenzene and tosylhydrazones gives rise to indene derivatives through a process that involves a carbene migratory insertion followed by an intramolecular carbopalladation, with the formation of two C-C bonds on the same carbon atom. The same strategy has also been applied for the synthesis of 2,3-disubstituted benzofurans and indenones by selecting the appropriate o-substituted iodoarene.
钯催化的邻碘烯丙基苯与甲苯磺酰腙之间的反应通过一个过程生成茚衍生物，该过程涉及卡宾迁移插入，随后是分子内碳钯化，在同一碳原子上形成两个碳-碳键。通过选择合适的邻位取代碘芳烃，同样的策略也已应用于2,3-二取代苯并呋喃和茚酮的合成。
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