刺果番荔枝茎皮水甲醇提取物的镇痛和自由基清除活性。

Analgesic and free radical scavenging activities of hydromethanolic extract of Crateva adansonii stem bark.

作者信息

Udeh Nkeiruka E, Onoja Samuel O

机构信息

Department of Veterinary Physiology, Pharmacology, Biochemistry and Animal Health and Production, College of Veterinary Medicine, Micheal Okpara University of Agriculture, PMB 7267, Umudike, Abia, Nigeria.

出版信息

J Intercult Ethnopharmacol. 2015 Jul-Sep;4(3):224-7. doi: 10.5455/jice.20150403055054. Epub 2015 May 8.

DOI:10.5455/jice.20150403055054

PMID:26401412

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4579496/

Abstract

BACKGROUND

Crateva adansonii is a moderately sized deciduous tree found throughout the tropics especially along the river banks. This study was aimed at the evaluation of the analgesic and antioxidant activities of the methanolic extract of C. adansonii stem-bark.

METHODS

The analgesic activity of Crateva extract was investigated using both chemical and thermal models of nociception in rodents while the antioxidant activity was evaluated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) photometric model.

RESULTS

The extract produced a minute concentration-dependent increase in free radical scavenging activities. The extract (100, 200, and 400 mg/kg) caused a significant (P < 0.05) dose-dependent reduction in the number of writhing in treated rats when compared to the negative control. The extract at 100, 200, 400 mg/kg, and pentazocine (3 mg/kg) increased the pain reaction time in the treated rats by 58.05%, 66.67%, 94.76%, and 79.40%, respectively, when compared to the negative control.

CONCLUSION

The C. adansonii stem bark possesses analgesic activity against peripheral and central mediated pain sensation and also antioxidant properties. This study justifies the ethnomedical use of C. adansonii in pain treatment.

摘要

背景

阿当凤榴是一种中等大小的落叶乔木，遍布热带地区，尤其生长在河岸。本研究旨在评估阿当凤榴茎皮甲醇提取物的镇痛和抗氧化活性。

方法

采用啮齿动物伤害感受的化学和热模型研究阿当凤榴提取物的镇痛活性，同时使用2,2-二苯基-1-苦基肼（DPPH）光度法模型评估抗氧化活性。

结果

提取物产生了微小的浓度依赖性自由基清除活性增加。与阴性对照相比，提取物（100、200和400mg/kg）使受试大鼠的扭体次数显著（P<0.05）剂量依赖性减少。与阴性对照相比，100、200、400mg/kg的提取物和喷他佐辛（3mg/kg）分别使受试大鼠的疼痛反应时间增加了58.05%、66.67%、94.76%和79.40%。