Steel Ariah J, Eslick Guy D
J Alzheimers Dis. 2015;47(2):351-64. doi: 10.3233/JAD-140822.
The role of infectious agents in the development of AD has long been debated, in particular, the herpesviridae family. We therefore conducted a meta-analysis to quantitatively assess all published data to establish whether there is an association. We identified studies that looked for the presence of viral DNA in the brain and/or antibody seropositivity in people with AD from four electronic databases. 35 studies met our inclusion criteria (AD cases = 1294; controls = 3059). There was an increased risk for AD when herpesviridae is present in the brain compared to controls [OR 1.38; 95% CI 1.14-1.66]. Sub-analysis showed that APOE ɛ4 and HSV1 together increased the risk of AD development [OR 2.71; 95% CI 1.08-6.80]. HSV1 together with the presence of the APOE ɛ4 allele increases the risk of developing AD.
感染因子在阿尔茨海默病（AD）发展过程中的作用长期以来一直存在争议，尤其是疱疹病毒科。因此，我们进行了一项荟萃分析，以定量评估所有已发表的数据，确定是否存在关联。我们从四个电子数据库中筛选了寻找AD患者大脑中病毒DNA存在情况和/或抗体血清阳性的研究。35项研究符合我们的纳入标准（AD病例 = 1294；对照 = 3059）。与对照组相比，大脑中存在疱疹病毒科时AD风险增加[比值比（OR）1.38；95%置信区间（CI）1.14 - 1.66]。亚组分析表明，APOE ε4和单纯疱疹病毒1型（HSV1）共同增加了AD发生风险[OR 2.71；95% CI 1.08 - 6.80]。HSV1与APOE ε4等位基因的存在共同增加了患AD的风险。
