Weimar Christian, Winkler Angela, Dlugaj Martha, Lehmann Nils, Hennig Frauke, Bauer Marcus, Kröger Knut, Kälsch Hagen, Mahabadi Amir-Abass, Dragano Nico, Moebus Susanne, Hoffmann Barbara, Jöckel Karl-Heinz, Erbel Raimund
Department of Neurology, University Hospital of Essen, University of Duisburg-Essen, Germany.
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Germany.
J Alzheimers Dis. 2015;47(2):433-42. doi: 10.3233/JAD-150218.
Several studies have reported an association of atherosclerosis with mild cognitive impairment (MCI) and dementia independent of cardiovascular risk factors.
To compare the cross-sectional association of the ankle-brachial index (ABI), intima media thickness (IMT), and coronary artery calcification (CAC) with MCI and its subtypes, amnestic MCI (aMCI) and non-amnestic MCI (naMCI) in the population-based Heinz Nixdorf Recall cohort study.
4,086 participants performed a validated brief cognitive assessment at the first follow-up examination (2006-2008). MCI was diagnosed according to previously published criteria. Prevalence ratio (PR) regression models adjusted for age, gender, education, cardiovascular risk factors, and APOE genotype were used to compare the association of the ABI, the CAC-Agatston score and the IMT with MCI and its subtypes.
We identified 490 participants with MCI (mean age 66.1 ± 7.8, 46.9 % male, aMCI n = 249, naMCI n = 241) and 1,242 cognitively normal participants. A decreasing ABI (per 0.1) was significantly associated with a higher MCI prevalence in fully adjusted models (PR 1.06; 95% confidence interval (CI) 1.01-1.11), whereas an increasing CAC (log(CAC+1)) or IMT (per 0.1 mm) were not associated after adjustment. A decreasing ABI was also significantly associated with naMCI in fully adjusted models (PR 1.12; CI 1.03-1.21) but not with aMCI.
Our data show that the degree of generalized atherosclerosis as measured by the ABI is associated with MCI and with naMCI in a population-based cohort.
多项研究报告称，动脉粥样硬化与轻度认知障碍（MCI）和痴呆有关，且独立于心血管危险因素。
在基于人群的海因茨·尼克斯多夫召回队列研究中，比较踝臂指数（ABI）、内膜中层厚度（IMT）和冠状动脉钙化（CAC）与MCI及其亚型，即遗忘型MCI（aMCI）和非遗忘型MCI（naMCI）的横断面关联。
4086名参与者在首次随访检查（2006 - 2008年）时进行了经过验证的简短认知评估。MCI根据先前公布的标准进行诊断。使用针对年龄、性别、教育程度、心血管危险因素和载脂蛋白E（APOE）基因型进行调整的患病率比（PR）回归模型，比较ABI、CAC - 阿加斯顿评分和IMT与MCI及其亚型的关联。
我们确定了490名MCI参与者（平均年龄66.1±7.8岁，46.9%为男性，aMCI有249名，naMCI有241名）和1242名认知正常的参与者。在完全调整的模型中，ABI降低（每降低0.1）与MCI患病率升高显著相关（PR 1.06；95%置信区间（CI）1.01 - 1.11），而调整后，CAC升高（log（CAC + 1））或IMT增加（每增加0.1毫米）则无关联。在完全调整的模型中，ABI降低也与naMCI显著相关（PR 1.12；CI 1.03 - 1.21），但与aMCI无关。
我们的数据表明，在基于人群的队列中，通过ABI测量的全身性动脉粥样硬化程度与MCI和naMCI有关。
