Chen Shi, Zhang Hao, Zhang Jianan, Jiang Hai, Fan Wenxiu, Zhang Xueyang, Jin Yibing, Yang Xiangdong, Mao Changqing, Peng Hao
Department of Nursing, the Second People's Hospital of Kunshan, Suzhou Vocational Health College, Suzhou, China.
Department of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
BMC Public Health. 2024 Aug 7;24(1):2149. doi: 10.1186/s12889-024-19700-6.
Vascular health has been associated with cognition but related evidence is limited in Chinese. The objective of this study was to examine the association of vascular aging assessed by arterial stiffness and blood pressure with cognitive function in an unselected Chinese population.
In the Tianning Cohort (N = 5158), indicators of arterial stiffness and blood pressure including carotid-femoral pulse wave velocity (cfPWV), ankle-brachial index (ABI), pulse pressure (PP), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured. Cognitive function was assessed using the Mini Mental State Examination (MMSE) questionnaire. We applied Poisson regression and logistic regression to examine the associations of vascular aging and blood pressure with cognitive function.
76 (1.47%) participants had impaired cognitive function diagnosed by a MMSE score of less than 24 points. Participants with a higher level of PP were more likely to have a decreased score of MMSE (β=-0.0121, P < 0.001 for log-transformed pulse pressure) and a higher risk of having impaired cognitive function (OR = 5.95, 95%CI: 2.02-17.79, P < 0.001 for log-transformed PP). Per standard deviation increment in SBP was significantly associated with lower MMSE score (β=-0.0020, P < 0.001) and impaired cognitive function (OR = 1.69, 95%CI: 1.38-2.06, P < 0.001). No significant associations were found regarding other parameters.
Blood pressure and hypertension were associated with cognitive function in Chinese adults. PP may be a potential predictor for impaired cognitive function.
血管健康与认知功能相关，但在中国相关证据有限。本研究的目的是在未经过筛选的中国人群中，研究通过动脉僵硬度和血压评估的血管老化与认知功能之间的关联。
在天宁队列（N = 5158）中，测量了动脉僵硬度和血压指标，包括颈股脉搏波速度（cfPWV）、踝臂指数（ABI）、脉压（PP）、收缩压（SBP）和舒张压（DBP）。使用简易精神状态检查表（MMSE）问卷评估认知功能。我们应用泊松回归和逻辑回归来研究血管老化和血压与认知功能之间的关联。
76名（1.47%）参与者被诊断为认知功能受损，其MMSE评分低于24分。PP水平较高的参与者更有可能出现MMSE评分降低（β=-0.0121，对数转换后的脉压P < 0.001），以及认知功能受损风险更高（OR = 5.95，95%CI：2.02 - 17.79，对数转换后的PP P < 0.001）。SBP每增加一个标准差与较低的MMSE评分（β=-0.0020，P < 0.001）和认知功能受损（OR = 1.69，95%CI：1.38 - 2.06，P < 0.001）显著相关。未发现其他参数有显著关联。
血压和高血压与中国成年人的认知功能相关。PP可能是认知功能受损的一个潜在预测指标。
