阿尔茨海默病患者脑脊液中淀粉样β蛋白种类与脑淀粉样蛋白的镜像关系

Mirror Image of the Amyloid-β Species in Cerebrospinal Fluid and Cerebral Amyloid in Alzheimer's Disease.

作者信息

Catania Marcella, Di Fede Giuseppe, Tonoli Elisa, Benussi Luisa, Pasquali Claudio, Giaccone Giorgio, Maderna Emanuela, Ghidoni Roberta, Tagliavini Fabrizio

机构信息

Division of Neurology 5 and Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Milan, Italy.

Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli, Brescia, Italy.

出版信息

J Alzheimers Dis. 2015;47(4):877-81. doi: 10.3233/JAD-150179.

DOI:10.3233/JAD-150179

PMID:26401767

Abstract

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) accumulation in brain that is paralleled by Aβ(1-42) reduction in cerebrospinal fluid (CSF). We analyzed the pattern of Aβ peptides, including the N- and C-terminal truncated fragments, in brain and CSF from two familial and one sporadic AD cases. We found that (i) each patient is characterized by a distinct Aβ profile in CSF and brain deposits and (ii) the CSF Aβ pattern mirrors the Aβ profile of cerebral amyloid. These results suggest the existence of different molecular AD subtypes which can be recognized by CSF analysis, enabling patient stratification.

摘要

阿尔茨海默病（AD）的特征是大脑中β淀粉样蛋白（Aβ）积聚，同时脑脊液（CSF）中Aβ(1-42)减少。我们分析了来自两个家族性和一个散发性AD病例的大脑和脑脊液中Aβ肽的模式，包括N端和C端截短片段。我们发现：（i）每位患者的脑脊液和脑沉积物中Aβ谱都各不相同；（ii）脑脊液Aβ模式反映了脑淀粉样蛋白的Aβ谱。这些结果表明存在不同的分子AD亚型，可通过脑脊液分析识别，从而实现患者分层。