Li Ge, Xiong Kangping, Korff Ane, Pan Catherine, Quinn Joseph F, Galasko Douglas R, Liu Chunfeng, Montine Thomas J, Peskind Elaine R, Zhang Jing
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
J Alzheimers Dis. 2015;47(4):883-7. doi: 10.3233/JAD-150420.
Clinically diagnosed Alzheimer's disease (AD) is pathologically heterogeneous. In this multicenter cohort of 215 clinically diagnosed AD patients and 249 controls, E-selectin and vascular cell adhesion molecule 1 (VACM-1) were measured along with amyloid-β peptide 1-42 (Aβ42) and tau. We discovered that E-selectin, a biomarker of endothelial function/vascular injury, was inversely correlated with cerebrospinal fluid (CSF) tau/Aβ42 ratio and significantly elevated in clinical AD patients without the typical AD CSF biomarker signature (i.e., low tau/Aβ42 ratio) compared to those with the signature. These findings suggest that E-selectin may be an objective biomarker related to vascular mechanisms contributing to dementia.
临床诊断的阿尔茨海默病（AD）在病理上具有异质性。在这个包含215名临床诊断为AD的患者和249名对照的多中心队列中，我们检测了E-选择素、血管细胞黏附分子1（VACM-1）以及淀粉样β肽1-42（Aβ42）和tau蛋白。我们发现，作为内皮功能/血管损伤生物标志物的E-选择素与脑脊液（CSF）tau/Aβ42比值呈负相关，并且在没有典型AD脑脊液生物标志物特征（即低tau/Aβ42比值）的临床AD患者中，其水平显著高于具有该特征的患者。这些发现表明，E-选择素可能是一种与导致痴呆的血管机制相关的客观生物标志物。
