Hatchette Todd F, Johnston B Lynn, Schleihauf Emily, Mask Angela, Haldane David, Drebot Michael, Baikie Maureen, Cole Teri J, Fleming Sarah, Gould Richard, Lindsay Robbin
Emerg Infect Dis. 2015 Oct;21(10):1751-8. doi: 10.3201/eid2110.141640.
Ixodes scapularis ticks, which transmit Borrelia burgdorferi, the causative agent of Lyme disease (LD), are endemic to at least 6 regions of Nova Scotia, Canada. To assess the epidemiology and prevalence of LD in Nova Scotia, we analyzed data from 329 persons with LD reported in Nova Scotia during 2002-2013. Most patients reported symptoms of early localized infection with rash (89.7%), influenza-like illness (69.6%), or both; clinician-diagnosed erythema migrans was documented for 53.2%. In a separate serosurvey, of 1,855 serum samples screened for antibodies to B. burgdorferi, 2 were borderline positive (both with an indeterminate IgG on Western blot), resulting in an estimated seroprevalence of 0.14% (95% CI 0.02%-0.51%). Although LD incidence in Nova Scotia has risen sharply since 2002 and is the highest in Canada (16/100,000 population in 2013), the estimated number of residents with evidence of infection is low, and risk is localized to currently identified LD-endemic regions.
肩突硬蜱传播莱姆病（LD）的病原体伯氏疏螺旋体，在加拿大新斯科舍省的至少6个地区为地方病。为评估新斯科舍省莱姆病的流行病学和患病率，我们分析了2002年至2013年期间新斯科舍省报告的329例莱姆病患者的数据。大多数患者报告有早期局限性感染的症状，如皮疹（89.7%）、流感样疾病（69.6%）或两者皆有；临床诊断的游走性红斑记录为53.2%。在一项单独的血清学调查中，在1855份筛查伯氏疏螺旋体抗体的血清样本中，有2份为临界阳性（两者在免疫印迹上的IgG均不确定），估计血清阳性率为0.14%（95%CI 0.02%-0.51%）。尽管自2002年以来新斯科舍省的莱姆病发病率急剧上升，且在加拿大最高（2013年为16/10万人口），但有感染证据的居民估计数量较低，且风险局限于目前确定的莱姆病流行地区。
