Liu Jia, Zhu Ming-wei, Arzberger Thomas, Wang Lu-ning
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, China.
J Alzheimers Dis. 2015;48(1):55-8. doi: 10.3233/JAD-150225.
A clinicopathological investigation was conducted on a case of an 89-year-old man with a 10-year history of progressive dementia who also suffered strokes, apathy, aphasia, dysarthria, weakness of both legs, and walking difficulties. At autopsy, we found an obvious atrophy of the frontal and temporal cortex. Lewy bodies (LBs) could be seen in brain stem, amygdala, and neocortex. Argyrophilic grains were observed in hippocampus, entorhinal cortex, neocortex, amygdala, and pons, as well as neurofibrillary tangles in the entorhinal cortex and hippocampus. The case presented here is a rare case of frontotemporal lobar degeneration with accumulation of argyrophilic grains and Lewy bodies.
对一名89岁男性进行了临床病理研究，该患者有10年进行性痴呆病史，还患有中风、淡漠、失语、构音障碍、双腿无力及行走困难。尸检时，我们发现额叶和颞叶皮质明显萎缩。在脑干、杏仁核和新皮质中可见路易小体（LB）。在海马体、内嗅皮质、新皮质、杏仁核和脑桥中观察到嗜银颗粒，在内嗅皮质和海马体中还观察到神经原纤维缠结。本文所呈现的病例是一例罕见的伴有嗜银颗粒和路易小体积聚的额颞叶变性。
