Giacomini Ana Cristina V V, Abreu Murilo S, Giacomini Luidia V, Siebel Anna M, Zimerman Fernanda F, Rambo Cassiano L, Mocelin Ricieri, Bonan Carla D, Piato Angelo L, Barcellos Leonardo J G
Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS 97105-900, Brazil; Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS 99052-900, Brazil.
Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS 97105-900, Brazil.
Behav Brain Res. 2016 Jan 1;296:301-310. doi: 10.1016/j.bbr.2015.09.027. Epub 2015 Sep 25.
Drug residue contamination in aquatic ecosystems has been studied extensively, but the behavioral effects exerted by the presence of these drugs are not well known. Here, we investigated the effects of acute stress on anxiety, memory, social interaction, and aggressiveness in zebrafish exposed to fluoxetine and diazepam at concentrations that disrupt the hypothalamic-pituitary-interrenal (HPI) axis. Stress increased the locomotor activity and time spent in the bottom area of the tank (novel tank). Fluoxetine and diazepam prevented these behaviors. We also observed that stress and fluoxetine and diazepam exposures decreased social interaction. Stress also increased aggressive behavior, which was not reversed by fluoxetine or diazepam. These data suggest that the presence of these drugs in aquatic ecosystems causes significant behavioral alterations in fish.
水生生态系统中的药物残留污染已得到广泛研究，但这些药物的存在所产生的行为影响尚不为人所知。在此，我们研究了急性应激对暴露于氟西汀和地西泮的斑马鱼的焦虑、记忆、社会互动和攻击性的影响，这些药物的浓度会破坏下丘脑 - 垂体 - 肾间组织（HPI）轴。应激增加了斑马鱼的运动活性以及在水箱底部区域（新水箱）所花费的时间。氟西汀和地西泮可预防这些行为。我们还观察到，应激以及氟西汀和地西泮暴露会减少社会互动。应激还增加了攻击性行为，而氟西汀或地西泮并未使其逆转。这些数据表明，这些药物在水生生态系统中的存在会导致鱼类出现显著的行为改变。
