Bai Jie, Zou Xingwei, Jiang Yougui, Wang Qiongyu
Department of Dermatology, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710004, China.E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2015 Aug;35(9):1349-51.
To investigate the expression of transient receptor potential lvanilloidreceptor 4 (TRPV4) protein in pemphigus vulgaris (PV), bullous pemphigoid (BP), dermatitis herpetiformis (DH), and epidermolysis bullosa acquisita (EBA), and explore the role of TRPV4 in the pathogenesis of these diseases.
TRPV4 protein in normal skin tissues and lesions of PV, BP, DH, and EBA were detected with immunohistochemistry.
The positivity rate of TRPV4 protein expression was 61.90% in PV, 81.81% in BP, 72.22% in DH, and 68.42% in EBA. TRPV4-positive rates in these lesions were significantly lower than the rate in normal skin tissues (93.33%) and also differed significantly among these lesions (PV<EBA<DH<BP).
Low TRPV4 expressions may affect the formation and reconstitution of skin connection. TRPV4 may play an role in the occurrence and development of autoimmune bullous skin disorders.
研究瞬时受体电位香草酸受体4（TRPV4）蛋白在寻常型天疱疮（PV）、大疱性类天疱疮（BP）、疱疹样皮炎（DH）及获得性大疱性表皮松解症（EBA）中的表达情况，并探讨TRPV4在这些疾病发病机制中的作用。
采用免疫组织化学方法检测正常皮肤组织以及PV、BP、DH和EBA皮损中TRPV4蛋白。
TRPV4蛋白表达阳性率在PV中为61.90%，BP中为81.81%，DH中为72.22%，EBA中为68.42%。这些皮损中的TRPV4阳性率显著低于正常皮肤组织中的阳性率（93.33%），且这些皮损之间也存在显著差异（PV<EBA<DH<BP）。
TRPV4低表达可能影响皮肤连接的形成与重建。TRPV4可能在自身免疫性大疱性皮肤病的发生和发展中起作用。
