疏水改性亚氨基糖碳炔基糖苷的一锅法合成：多羟基四氢吲哚嗪的简便合成
One-Pot Synthesis of Hydrophobically Modified Iminosugar C-Alkynylglycosides: Facile Synthesis of Polyhydroxy Tetrahydroindolizines.
作者信息
Senthilkumar Soundararasu, Prasad Sure Siva, Das Amrita, Baskaran Sundarababu
机构信息
Department of Chemistry, Indian Institute of Technology Madras, Chennai-600036 (India).
出版信息
Chemistry. 2015 Nov 2;21(45):15914-8. doi: 10.1002/chem.201503047. Epub 2015 Sep 25.
A mild and efficient one-pot method has been developed for the stereoselective synthesis of structurally diverse novel iminosugar C-alkynylglycosides. The generality of this methodology has been demonstrated with a wide variety of amines and copper acetylides. This one-pot method has been exploited in the synthesis of new class of DNA cross-linking agents, polyhydroxy 1-vinyl-tetrahydroindolizine derivatives.
已开发出一种温和且高效的一锅法，用于立体选择性合成结构多样的新型亚氨基糖C-炔基糖苷。该方法的通用性已通过多种胺类和乙炔铜得以证明。这种一锅法已被用于合成一类新型的DNA交联剂——多羟基1-乙烯基-四氢吲哚嗪衍生物。
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