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NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia.NUDT15基因c.415C>T位点变异增加了急性淋巴细胞白血病患儿维持治疗期间6-巯基嘌呤诱导的骨髓抑制风险。
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Effect of ITPA Polymorphism on Adverse Drug Reactions of 6-Mercaptopurine in Pediatric Patients with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis.ITPA基因多态性对儿童急性淋巴细胞白血病患者6-巯基嘌呤药物不良反应的影响：一项系统评价和荟萃分析
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[Effect of genetic polymorphism of TPMT and NUDT15 on the tolerance of 6-mercaptopurine therapy in adult acute lymphoblastic leukemia].[TPMT和NUDT15基因多态性对成人急性淋巴细胞白血病6-巯基嘌呤治疗耐受性的影响]
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Meta-Analysis of Genetic Polymorphism on Thiopurine-Induced Myelosuppression in Asian Populations.亚洲人群中硫嘌呤诱导骨髓抑制的基因多态性的Meta分析。
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本文引用的文献

1
Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.日本急性淋巴细胞白血病儿童中NUDT15变异导致的6-巯基嘌呤毒性易感性。
Br J Haematol. 2015 Oct;171(1):109-15. doi: 10.1111/bjh.13518. Epub 2015 Jun 2.
2
Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.遗传性NUDT15变异是急性淋巴细胞白血病患儿巯嘌呤不耐受的遗传决定因素。
J Clin Oncol. 2015 Apr 10;33(11):1235-42. doi: 10.1200/JCO.2014.59.4671. Epub 2015 Jan 26.
3
Outcome of acute lymphoblastic leukemia treatment using national protocols at the Queen Sirikit National Institute of Child Health.
J Med Assoc Thai. 2014 Jun;97 Suppl 6:S1-5.
4
A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia.NUDT15基因中的一种常见错义变异会使人易患硫嘌呤诱导的白细胞减少症。
Nat Genet. 2014 Sep;46(9):1017-20. doi: 10.1038/ng.3060. Epub 2014 Aug 10.
5
Mercaptopurine/Methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction.巯嘌呤/甲氨蝶呤维持治疗儿童急性淋巴细胞白血病：临床的真相与假象
J Pediatr Hematol Oncol. 2014 Oct;36(7):503-17. doi: 10.1097/MPH.0000000000000206.
6
Implementation of TPMT testing.硫嘌呤甲基转移酶（TPMT）检测的实施
Br J Clin Pharmacol. 2014 Apr;77(4):704-14. doi: 10.1111/bcp.12226.
7
Children's Oncology Group's 2013 blueprint for research: acute lymphoblastic leukemia.儿童肿瘤学组 2013 年研究蓝图：急性淋巴细胞白血病。
Pediatr Blood Cancer. 2013 Jun;60(6):957-63. doi: 10.1002/pbc.24420. Epub 2012 Dec 19.
8
The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children.肌苷三磷酸焦磷酸酶的活性会影响日本儿童急性淋巴细胞白血病维持治疗期间 6-巯基嘌呤的毒性。
Leuk Res. 2012 May;36(5):560-4. doi: 10.1016/j.leukres.2011.11.015. Epub 2011 Dec 24.
9
Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine.ITPA 94C＞A 多态性与接受 6-巯基嘌呤治疗的急性淋巴细胞白血病患者不良事件风险的关系。
J Clin Pharm Ther. 2012 Apr;37(2):237-41. doi: 10.1111/j.1365-2710.2011.01272.x. Epub 2011 May 5.
10
Impact of the heterozygous TPMT*1/*3C genotype on azathioprine-induced myelosuppression in kidney transplant recipients in Thailand.杂合子TPMT*1/*3C基因型对泰国肾移植受者硫唑嘌呤诱导的骨髓抑制的影响。
Clin Ther. 2009 Jul;31(7):1524-33. doi: 10.1016/j.clinthera.2009.07.008.

NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia.

作者信息

Chiengthong Kanhatai, Ittiwut Chupong, Muensri Sasipa, Sophonphan Jiratchaya, Sosothikul Darintr, Seksan Panya, Suppipat Koramit, Suphapeetiporn Kanya, Shotelersuk Vorasuk

机构信息

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok.

Central Laboratory, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok.

出版信息

Haematologica. 2016 Jan;101(1):e24-6. doi: 10.3324/haematol.2015.134775. Epub 2015 Sep 24.

DOI:10.3324/haematol.2015.134775
PMID:26405151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4697903/
Abstract
摘要