Arimoto Maya Kato, Nakamoto Yuji, Nakatani Koya, Ishimori Takayoshi, Yamashita Kouhei, Takaori-Kondo Akifumi, Togashi Kaori
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54, Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto 606-8507 Japan.
Department of Diagnostic Radiology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama 710-0052 Japan.
Springerplus. 2015 Sep 17;4:521. doi: 10.1186/s40064-015-1339-2. eCollection 2015.
The aim of this retrospective study was to evaluate the characteristics of increased bone marrow uptake of 18F-FDG in patients with leukemia who underwent whole-body 18F-FDG PET/CT. The 18F-FDG PET/CT images of 9 patients with histologically proven leukemia were reviewed. The accumulation of 18F-FDG in the bone marrow was evaluated, and was compared with histological subtype, clinical course, and hematological findings. Nine patients (4 males, 5 females; age range, 5-58 years) had increased bone marrow uptake of 18F-FDG, including 6 patients with acute lymphoblastic leukemia, 1 with acute myeloid leukemia, 1 with chronic myeloid leukemia, and 1 with mature B cell neoplasm. Bone marrow uptake was generally diffuse but focal or inhomogeneous uptake was common, especially in the upper and lower extremities. Patients with increased bone marrow uptake of 18F-FDG commonly complained of fever and bone pain. No correlations between 18F-FDG uptake and peripheral blood findings were observed. Patients with leukemia may have increased bone marrow uptake of 18F-FDG on PET/CT, possibly reflecting leukemic cell activity. Leukemia can be included in the differential diagnosis when increased bone marrow uptake of 18F-FDG is observed.
本回顾性研究的目的是评估接受全身18F-FDG PET/CT检查的白血病患者骨髓18F-FDG摄取增加的特征。回顾了9例经组织学证实为白血病患者的18F-FDG PET/CT图像。评估了18F-FDG在骨髓中的蓄积情况，并将其与组织学亚型、临床病程及血液学检查结果进行比较。9例患者（4例男性，5例女性；年龄范围5至58岁）骨髓18F-FDG摄取增加，其中6例为急性淋巴细胞白血病，1例为急性髓细胞白血病，1例为慢性髓细胞白血病，1例为成熟B细胞肿瘤。骨髓摄取通常为弥漫性，但局灶性或不均匀摄取也很常见，尤其是在上下肢。骨髓18F-FDG摄取增加的患者常主诉发热和骨痛。未观察到18F-FDG摄取与外周血检查结果之间存在相关性。白血病患者在PET/CT上可能出现骨髓18F-FDG摄取增加，这可能反映了白血病细胞的活性。当观察到骨髓18F-FDG摄取增加时，白血病可纳入鉴别诊断。
