无人驾车？直击癌症转录。
No driver behind the wheel? Targeting transcription in cancer.
机构信息
Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Cell. 2015 Sep 24;163(1):28-30. doi: 10.1016/j.cell.2015.09.013.
Exploiting the dependence of cancer cells on transcription can be used as an effective strategy for targeting aggressive and therapeutically recalcitrant tumors. Wang et al. show that inhibiting transcription using THZ1, a small-molecule inhibitor of cyclin-dependent kinase CDK7, induces apoptotic cell death in triple-negative breast cancers.
利用癌细胞对转录的依赖性可以作为靶向侵袭性和治疗抗性肿瘤的有效策略。Wang 等人表明，使用小分子 CDK7 抑制剂 THZ1 抑制转录会诱导三阴性乳腺癌细胞发生凋亡性细胞死亡。
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