法洛四联症相关性肝病：一种新兴流行病及管理方案综述
Fontan Liver Disease: Review of an Emerging Epidemic and Management Options.
作者信息
Bradley Elisa, Hendrickson Benjamin, Daniels Curt
机构信息
Department of Internal Medicine, Division of Cardiovascular Medicine, Ohio State University, Columbus, OH, USA.
Division Cardiovascular Medicine, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
出版信息
Curr Treat Options Cardiovasc Med. 2015 Nov;17(11):51. doi: 10.1007/s11936-015-0412-z.
Abstract
Adults with complex congenital heart disease that resulted in a Fontan procedure frequently experience late cardiac failure. Increasingly, liver disease is recognized as an important complication of single-ventricle anatomy and Fontan physiology; however, there is no consensus regarding liver evaluation in this population. Here, we review what is known about liver disease in this unique group and propose screening and prevention measures. We also review controversial treatment areas including assist devices and transplantation, with a review of outcomes in isolated heart and combined heart-liver transplant.
摘要
因实施Fontan手术而患有复杂先天性心脏病的成人经常会出现晚期心力衰竭。越来越多的人认识到，肝脏疾病是单心室解剖结构和Fontan生理状态的重要并发症；然而，对于这一人群的肝脏评估尚无共识。在此，我们回顾了关于这一特殊群体肝脏疾病的已知情况，并提出筛查和预防措施。我们还回顾了包括辅助装置和移植在内的有争议的治疗领域，并对单纯心脏移植和心脏-肝脏联合移植的结果进行了综述。
相似文献
1
Fontan Liver Disease: Review of an Emerging Epidemic and Management Options.
Curr Treat Options Cardiovasc Med. 2015 Nov;17(11):51. doi: 10.1007/s11936-015-0412-z.
2
Heart and heart-liver transplantation in adults with failing Fontan physiology.
Clin Transplant. 2018 Aug;32(8):e13329. doi: 10.1111/ctr.13329. Epub 2018 Jul 18.
3
Single-center outcomes of combined heart and liver transplantation in the failing Fontan.
Clin Transplant. 2017 Mar;31(3). doi: 10.1111/ctr.12892. Epub 2017 Feb 4.
4
Fontan-associated liver disease: A review.
J Cardiol. 2019 Sep;74(3):223-232. doi: 10.1016/j.jjcc.2019.02.016. Epub 2019 Mar 28.
5
The failing Fontan: what's NEXT...?
Perfusion. 2014 Jan;29(1):89-93. doi: 10.1177/0267659113495913. Epub 2013 Jul 10.
6
Portal and centrilobular hepatic fibrosis in Fontan circulation and clinical outcomes.
J Heart Lung Transplant. 2015 Jul;34(7):883-91. doi: 10.1016/j.healun.2015.01.993. Epub 2015 Feb 11.
7
Anesthesia for Combined Heart-Liver Transplantation: A Narrative Review.
J Cardiothorac Vasc Anesth. 2024 Sep;38(9):2059-2069. doi: 10.1053/j.jvca.2024.03.036. Epub 2024 Mar 27.
8
Surgical revisions and mechanical support of the failing Fontan.
Cardiol Young. 2013 Dec;23(6):847-51. doi: 10.1017/S1047951113001674.
9
Short-term outcomes of en bloc combined heart and liver transplantation in the failing Fontan.
Clin Transplant. 2019 Jun;33(6):e13540. doi: 10.1111/ctr.13540. Epub 2019 Apr 11.
10
An Emphasis on Screening to Detect Liver Cirrhosis and Hepatocellular Carcinoma in Patients Having Undergone the Fontan Procedure in Early Childhood.
Case Rep Gastroenterol. 2020 Nov 23;14(3):615-623. doi: 10.1159/000510332. eCollection 2020 Sep-Dec.
引用本文的文献
1
Fontan-Associated Liver Disease.
Semin Liver Dis. 2025 Mar;45(1):114-128. doi: 10.1055/a-2556-4897. Epub 2025 Mar 13.
2
Alcohol use is prevalent among adults with the fontan circulation but does not correlate with liver disease.
Int J Cardiol Congenit Heart Dis. 2022 Jan 26;7:100339. doi: 10.1016/j.ijcchd.2022.100339. eCollection 2022 Mar.
3
Pediatric Combined Heart-liver Transplantation: A Single-center Long-term Experience.
Transplant Direct. 2024 Aug 19;10(9):e1696. doi: 10.1097/TXD.0000000000001696. eCollection 2024 Sep.
4
Poor correlation of 2D shear wave elastography and transient elastography in Fontan-associated liver disease: A head-to-head comparison.
JGH Open. 2023 Sep 14;7(10):690-697. doi: 10.1002/jgh3.12967. eCollection 2023 Oct.
5
Liver function monitoring in Fontan-procedure patients: audit of current practice across South Wales.
Br J Cardiol. 2021 Jun 2;28(3):29. doi: 10.5837/bjc.2021.029. eCollection 2021.
6
Gravity assistance enables liver stiffness measurements to detect liver fibrosis under congestive circumstances.
World J Hepatol. 2022 Apr 27;14(4):778-790. doi: 10.4254/wjh.v14.i4.778.
7
Spectrum of Fontan-associated liver disease assessed by MRI and US in young adolescents.
Abdom Radiol (NY). 2021 Jul;46(7):3205-3216. doi: 10.1007/s00261-021-02994-0. Epub 2021 Mar 10.
8
An Emphasis on Screening to Detect Liver Cirrhosis and Hepatocellular Carcinoma in Patients Having Undergone the Fontan Procedure in Early Childhood.
Case Rep Gastroenterol. 2020 Nov 23;14(3):615-623. doi: 10.1159/000510332. eCollection 2020 Sep-Dec.
9
Pediatric Fontan Associated Liver Disease: Non-invasive Evaluation with Serologic Markers and Acoustic Radiation Force Impulse (ARFI) Elastography.
Prog Pediatr Cardiol. 2019 Jun;53:21-27. doi: 10.1016/j.ppedcard.2018.09.004. Epub 2018 Oct 6.
10
Assessing hepatic impairment in Fontan-associated liver disease using the HepQuant SHUNT test.
Congenit Heart Dis. 2019 Nov;14(6):978-986. doi: 10.1111/chd.12831. Epub 2019 Aug 1.
本文引用的文献
1
Combined heart and liver transplantation against positive cross-match for patient with hypoplastic left heart syndrome.
Transplantation. 2014 Dec 27;98(12):e100-2. doi: 10.1097/TP.0000000000000542.
2
Improved systemic saturation after ventricular assist device implantation in a patient with decompensated dextro-transposition of the great arteries after the Fontan procedure.
Tex Heart Inst J. 2015 Feb 1;42(1):40-3. doi: 10.14503/THIJ-13-3374. eCollection 2015 Feb.
3
Portal and centrilobular hepatic fibrosis in Fontan circulation and clinical outcomes.
J Heart Lung Transplant. 2015 Jul;34(7):883-91. doi: 10.1016/j.healun.2015.01.993. Epub 2015 Feb 11.
4
Combination of liver biopsy with MELD-XI scores for post-transplant outcome prediction in patients with advanced heart failure and suspected liver dysfunction.
J Heart Lung Transplant. 2015 Jul;34(7):873-82. doi: 10.1016/j.healun.2014.12.009. Epub 2014 Dec 23.
5
Liver fibrosis in adults with Fontan palliation: Do common screening studies predict disease severity?
Int J Cardiol. 2015 Feb 15;181:174-5. doi: 10.1016/j.ijcard.2014.12.031. Epub 2014 Dec 3.
6
Outcomes of a hepatitis C screening protocol in at-risk adults with prior cardiac surgery.
World J Pediatr Congenit Heart Surg. 2014 Oct;5(4):503-6. doi: 10.1177/2150135114547587.
7
Novel techniques of mechanical circulatory support for the right heart and Fontan circulation.
Int J Cardiol. 2014 Oct 20;176(3):828-32. doi: 10.1016/j.ijcard.2014.08.012. Epub 2014 Aug 8.
8
Combined heart and liver transplantation can be safely performed with excellent short- and long-term results.
Ann Thorac Surg. 2014 Sep;98(3):858-62. doi: 10.1016/j.athoracsur.2014.04.100. Epub 2014 Jul 25.
9
Favourable mid-term outcome after heart transplantation for late Fontan failure.
Eur J Cardiothorac Surg. 2015 Apr;47(4):665-71. doi: 10.1093/ejcts/ezu280. Epub 2014 Jul 17.
10
Congestive hepatopathy after Fontan operation and related factors assessed by transient elastography.
J Thorac Cardiovasc Surg. 2014 Oct;148(4):1498-505. doi: 10.1016/j.jtcvs.2014.04.010. Epub 2014 Apr 13.
Zotero 插件