Bradley Elisa, Hendrickson Benjamin, Daniels Curt
Department of Internal Medicine, Division of Cardiovascular Medicine, Ohio State University, Columbus, OH, USA.
Division Cardiovascular Medicine, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
Curr Treat Options Cardiovasc Med. 2015 Nov;17(11):51. doi: 10.1007/s11936-015-0412-z.
Adults with complex congenital heart disease that resulted in a Fontan procedure frequently experience late cardiac failure. Increasingly, liver disease is recognized as an important complication of single-ventricle anatomy and Fontan physiology; however, there is no consensus regarding liver evaluation in this population. Here, we review what is known about liver disease in this unique group and propose screening and prevention measures. We also review controversial treatment areas including assist devices and transplantation, with a review of outcomes in isolated heart and combined heart-liver transplant.
因实施Fontan手术而患有复杂先天性心脏病的成人经常会出现晚期心力衰竭。越来越多的人认识到，肝脏疾病是单心室解剖结构和Fontan生理状态的重要并发症；然而，对于这一人群的肝脏评估尚无共识。在此，我们回顾了关于这一特殊群体肝脏疾病的已知情况，并提出筛查和预防措施。我们还回顾了包括辅助装置和移植在内的有争议的治疗领域，并对单纯心脏移植和心脏-肝脏联合移植的结果进行了综述。
