Uppal Sheetal, Jawali Narendra
Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
Res Microbiol. 2016 Jan;167(1):58-62. doi: 10.1016/j.resmic.2015.09.001. Epub 2015 Sep 25.
Bacterial persisters represent a small number of slow-growing antibiotic-tolerant cells among populations of rapidly growing cells, and are the main cause of frequent recurrent infections. MqsR-MqsA, the toxin-antitoxin (TA) pair, is the most frequently induced TA system associated with antibiotic persistence in Escherichia coli. In this study, we show that the cyclic AMP receptor protein (CRP) indirectly upregulates mqsRA transcription. We also show that CRP plays an important role in antibiotic persistence, which seems to be partially mediated through MqsRA. Overall, this study highlights the role of CRP as an important regulator of antibiotic persistence in E. coli.
细菌持留菌是快速生长的细胞群体中一小部分生长缓慢、耐受抗生素的细胞，是频繁复发感染的主要原因。毒素-抗毒素（TA）对MqsR-MqsA是大肠杆菌中与抗生素耐受性相关的最常被诱导的TA系统。在本研究中，我们发现环磷酸腺苷受体蛋白（CRP）间接上调mqsRA的转录。我们还表明CRP在抗生素耐受性中起重要作用，这似乎部分是通过MqsRA介导的。总体而言，本研究突出了CRP作为大肠杆菌中抗生素耐受性重要调节因子的作用。
