浸润性膀胱癌患者“正常”尿路上皮的扫描电子显微镜检查
Scanning electron microscopy of 'normal' urothelium in patients with infiltrating bladder carcinoma.
作者信息
Parenti A, Capitanio G, De Caro R, Dalla Palma P
机构信息
Institute of Pathological Anatomy, University of Padua, Italy.
出版信息
Appl Pathol. 1989;7(6):338-43.
'Normal' dome biopsies from 20 cystectomies for infiltrating bladder carcinomas were studied with scanning electron microscopy (SEM). All cases showed alterations ranging from minimal changes to numerous pleomorphic microvilli, and were classified according to Herd and Jacobs. The SEM findings and grades were correlated with dome histology and the results were quite good. However, in our opinion, the Herd and Jacobs classification and subclassifications are poorly reproducible without morphometric analysis. Nevertheless the SEM study is useful to strengthen the diagnosis of dysplasia/carcinoma in situ in 'healthy'-looking urothelium.
对20例因浸润性膀胱癌行膀胱切除术所取的“正常”穹窿部活检组织进行了扫描电子显微镜（SEM）研究。所有病例均显示出从微小改变到大量多形性微绒毛的改变，并根据赫德（Herd）和雅各布斯（Jacobs）的方法进行分类。SEM结果和分级与穹窿部组织学相关，结果相当不错。然而，我们认为，在没有形态计量分析的情况下，赫德和雅各布斯的分类及亚分类很难重复。尽管如此，SEM研究对于加强对看似“健康”的尿路上皮发育异常/原位癌的诊断是有用的。
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