McKenna Faye, Koo Bang-Bon, Killiany Ronald
Bioimaging Program, Boston University School of Medicine, 650 Albany Street, Boston, MA, 02118, USA.
Department of Anatomy and Neurobiology, Boston University School of Medicine, 72 East Concord Street, Boston, MA, 02118, USA.
Brain Imaging Behav. 2016 Dec;10(4):970-983. doi: 10.1007/s11682-015-9451-z.
In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) scans from subjects with early mild cognitive impairment (EMCI) and control subjects to study functional network connectivity. The scans were acquired by the Alzheimer's Disease Neuroimaging Initiative (ADNI). We used genetic data from the ADNI database to further subdivide the EMCI and control groups into genotype groups with or without the Apolipoprotein E allele e4 (APOE e4). Region of interest (ROI)-to-ROI resting-state functional connectivity was measured using Freesurfer and the Functional Connectivity Toolbox for Matlab (CONN). In our analysis, we compared whole-brain ROI connectivity strength and ROI-to-ROI functional network connectivity strength between EMCI, control and genotype subject groups. We found that the ROI network properties were disrupted in EMCI and APOE e4 carrier groups. Notably, we show that (1) EMCI disrupts functional connectivity strength in many important functionally-linked areas; (2) APOE e4 disrupts functional connectivity strength in similar areas to EMCI; and (3) the differences in functional connectivity between groups shows a multifactor contribution to functional network dysfunction along the trajectory leading to dementia.
在本研究中，我们使用了来自早期轻度认知障碍（EMCI）受试者和对照受试者的静息态功能磁共振成像（rs-fMRI）扫描数据来研究功能网络连通性。这些扫描数据由阿尔茨海默病神经成像计划（ADNI）获取。我们使用ADNI数据库中的基因数据，将EMCI组和对照组进一步细分为携带或不携带载脂蛋白E等位基因e4（APOE e4）的基因型组。使用Freesurfer和用于Matlab的功能连通性工具箱（CONN）测量感兴趣区域（ROI）到ROI的静息态功能连通性。在我们的分析中，我们比较了EMCI组、对照组和基因型受试者组之间全脑ROI连通性强度以及ROI到ROI功能网络连通性强度。我们发现，ROI网络特性在EMCI组和APOE e4携带者组中受到破坏。值得注意的是，我们发现：（1）EMCI在许多重要的功能连接区域破坏了功能连通性强度；（2）APOE e4在与EMCI相似的区域破坏了功能连通性强度；（3）组间功能连通性的差异显示了在导致痴呆的病程中，多种因素对功能网络功能障碍的影响。
