Correia Bárbara, Freitas Rosa, Figueira Etelvina, Soares Amadeu M V M, Nunes Bruno
Department of Biology, Centro de Estudos do Ambiente e do MAR (CESAM), University of Aveiro, Portugal.
Department of Biology, Centro de Estudos do Ambiente e do MAR (CESAM), University of Aveiro, Portugal.
Comp Biochem Physiol C Toxicol Pharmacol. 2016 Jan;179:116-24. doi: 10.1016/j.cbpc.2015.09.006. Epub 2015 Sep 26.
Paracetamol, a drug with analgesic and antipyretic properties, is one of the most used substances in human therapeutics, being also frequently detected in aquatic environments. Recent studies report its toxicity towards aquatic species, but the overall amount of data concerning its effects is still scarce. Global changes, likely alterations in abiotic conditions, including salinity, can modulate the interactions of contaminants with biota, conditioning the toxicological responses elicited also by pharmaceuticals. The present article describes the oxidative toxic effects posed by paracetamol on the clam species Ruditapes philippinarum under different salinity conditions. The results demonstrated the establishment of an oxidative-based effect, with significant alteration of several parameters, such as superoxide dismutase (SOD) and the ratio of reduced/oxidized glutathione (GSH/GSSG). Water salinity influenced the response of clams exposed to different paracetamol concentrations, showing the importance of studying physiological traits under realistic test conditions, which are likely to vary in great extent as a result of climate change.
对乙酰氨基酚是一种具有止痛和解热特性的药物，是人类治疗中最常用的物质之一，在水生环境中也经常被检测到。最近的研究报告了其对水生物种的毒性，但有关其影响的总体数据仍然稀缺。全球变化，可能包括盐度等非生物条件的改变，会调节污染物与生物群的相互作用，也会影响药物引发的毒理学反应。本文描述了在不同盐度条件下，对乙酰氨基酚对菲律宾蛤仔的氧化毒性作用。结果表明建立了基于氧化的效应，几个参数发生了显著变化，如超氧化物歧化酶（SOD）和还原型/氧化型谷胱甘肽比值（GSH/GSSG）。水的盐度影响了暴露于不同对乙酰氨基酚浓度下蛤仔的反应，这表明在现实的测试条件下研究生理特征的重要性，由于气候变化，这些条件可能会有很大程度的变化。
