Högberg Göran, Antonuccio David O, Healy David
Department of Women's and Children's Health, Child and Adolescent Psychiatric Unit, Karolinska Institutet, Astrid Lindgren Children's Hospital, Stockholm, Sweden.
Stockholm Child and Adolescent Psychiatry, BUP Huddinge, Stockholm, Sweden.
Int J Risk Saf Med. 2015;27(2):85-91. doi: 10.3233/JRS-150645.
Completed suicides are a major cause of death in adolescents in Sweden. Forensic analysis of completed suicides in children and adolescents shows there is one completed suicide per 1000 children taking a selective serotonin re-uptake inhibitor (SSRI). In order to elucidate these events we undertook a study of the results and reporting of suicidal events in the Treatment of Adolescents with Depression Study (TADS). We conclude that a major, albeit underreported, finding in the TADS was the significant increase of suicidal events in the adolescents on antidepressant medication in comparison to the group on placebo medication. The proportions of suicidal events were 11% and 2.7% respectively. This increased risk of suicidal events might be related to the high incidence of medication with an SSRI in the group of completed suicides among Swedish adolescents.
在瑞典，自杀身亡是青少年死亡的主要原因。对儿童和青少年自杀身亡案例的法医分析表明，每1000名服用选择性5-羟色胺再摄取抑制剂（SSRI）的儿童中就有1例自杀身亡。为了阐明这些事件，我们对青少年抑郁症治疗研究（TADS）中的自杀事件结果及报告进行了一项研究。我们得出的结论是，TADS中一个主要的（尽管未被充分报道）发现是，与服用安慰剂的青少年组相比，服用抗抑郁药物的青少年自杀事件显著增加。自杀事件的比例分别为11%和2.7%。自杀事件风险的增加可能与瑞典青少年自杀身亡案例中服用SSRI药物的高发生率有关。
