Shariff Farhana, Peters Paul A, Arbour Laura, Greenwood Margo, Skarsgard Erik, Brindle Mary
University of British Columbia, Vancouver, BC, Canada.
University of New Brunswick, New Brunswick, Canada.
Pediatr Surg Int. 2015 Nov;31(11):1055-60. doi: 10.1007/s00383-015-3797-6. Epub 2015 Sep 26.
The incidence of gastroschisis (GS) has increased globally. Maternal age and smoking are risk factors and aboriginal communities may be more commonly affected. Factors leading to this increased incidence are otherwise unclear. We investigate maternal sociodemography, air pollution and personal risk factors comparing mothers of infants with GS with a control group of infants with diaphragmatic hernia (CDH) in a large population-based analysis.
Data were collected from a national, disease-specific pediatric surgical database (May 2006-June 2013). Maternal community sociodemographic information was derived from the Canadian 2006 Census. Univariate and multivariable analyses were performed examining maternal factors related to diagnosis of GS.
GS infants come from poorer, less educated communities with more unemployment, less pollution, fewer immigrants, and more aboriginal peoples than infants with CDH. Teen maternal age, smoking, and illicit drug use, are associated with GS.
Mothers of infants with GS are younger, more likely to smoke and come from socially disadvantaged communities with higher proportions of aboriginal peoples but lower levels of air pollution compared to mothers of CDH infants. Identification of maternal risks provides direction for prenatal screening and public health interventions.
腹裂（GS）的全球发病率呈上升趋势。母亲年龄和吸烟是风险因素，原住民社区可能更易受影响。导致发病率上升的其他因素尚不清楚。在一项基于大规模人群的分析中，我们比较了GS患儿母亲与膈疝（CDH）患儿母亲这一对照组的母亲社会人口统计学、空气污染及个人风险因素。
数据收集自一个全国性的、特定疾病的儿科外科数据库（2006年5月至2013年6月）。母亲社区社会人口统计学信息源自2006年加拿大人口普查。进行单变量和多变量分析，以检验与GS诊断相关的母亲因素。
与CDH患儿相比，GS患儿来自更贫困、教育程度更低、失业率更高、污染更少、移民更少且原住民更多的社区。青少年母亲年龄、吸烟和使用非法药物与GS有关。
与CDH患儿的母亲相比，GS患儿的母亲更年轻，更有可能吸烟，来自社会处境不利的社区，原住民比例更高，但空气污染水平更低。识别母亲风险可为产前筛查和公共卫生干预提供方向。
