White L, Said M, Rais-Bahrami K
J Neonatal Perinatal Med. 2015;8(2):157-63. doi: 10.3233/NPM-15814090.
To monitor altered mesenteric tissue oxygen saturation (StO2) before and after blood transfusion.
We placed a 4-wavelength NIRS sensor (FORE-SIGHT, CASMED, Branford, CT USA) on the right lower abdominal quadrant prior to transfusion and measured StO2 for up to 48 hours post transfusion. Pulse oximetry (SpO2) data was collected simultaneously, with fractional tissue oxygen extraction (FTOE) and the [SpO2-StO2] difference calculated to normalize for hypoxic episodes. All data was combined and averaged in 30 minute windows for events before, during, and post transfusion to determine long term trends and analyzed using Repeated Measures ANOVA. 24 infants were enrolled in this study with 36 hours of data collected for 23 subjects and 48 hours for 16 subjects.
We found no significant differences in any of the parameters when compared pre and post transfusion values at 3, 6, 12, 24 and 36 hours post transfusion. For the 16 subjects monitored to 48 hours, there was a significant decrease in FTOE and near significant increase in StO2 and reciprocal decrease in [SpO2 - StO2] at 48 hours post transfusion.
There are several plausible mechanisms that may explain the relationship between necrotizing enterocolitis and PRBC transfusion; however, mesenteric tissue oxygen saturation changes did not clearly show that ischemia or re-perfusion injury to be one of the potential mechanisms.
监测输血前后肠系膜组织氧饱和度（StO2）的变化。
在输血前，我们将一个四波长近红外光谱传感器（FORE-SIGHT，CASMED，美国康涅狄格州布兰福德）放置在右下腹部象限，并在输血后长达48小时内测量StO2。同时收集脉搏血氧饱和度（SpO2）数据，计算组织氧提取分数（FTOE）以及[SpO2-StO2]差值，以对缺氧发作进行标准化。所有数据在输血前、输血期间和输血后的事件中，以30分钟为窗口进行合并和平均，以确定长期趋势，并使用重复测量方差分析进行分析。本研究纳入了24名婴儿，23名受试者收集了36小时的数据，16名受试者收集了48小时的数据。
在输血后3、6、12、24和36小时，比较输血前后的值时，我们发现任何参数均无显著差异。对于监测至48小时的16名受试者，输血后48小时FTOE显著降低，StO2近乎显著升高，[SpO2 - StO2]呈反向降低。
有几种合理的机制可以解释坏死性小肠结肠炎与红细胞悬液输血之间的关系；然而，肠系膜组织氧饱和度变化并未明确表明缺血或再灌注损伤是潜在机制之一。
