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[白塞病的免疫抑制治疗。长期结果]

[Immunosuppressive treatment of Behçet's syndrome. Long-term results].

作者信息

Martenet A C, Paccolat F

出版信息

Ophtalmologie. 1989 Jan-Mar;3(1):40-2.

PMID:2641069
Abstract

We present middle and long-term results of cyclophosphamide and procarbazine therapy of Behçet's uveitis. Of 45 patients, 20 were followed for 1-4 years (14 successful cases, 5 satisfactory results with regression of inflammatory signs but no functional improvement, 1 failure), 17 for 5-10 years (9 successes, 5 satisfactory results, 3 failures), and 8 for 11-16 years (2 successes, 2 satisfactory results, 4 failures). The high percentage of success (over 55%) could be attributed partly to the early onset of therapy and may be partly to the choice of drugs.

摘要

我们展示了环磷酰胺和丙卡巴肼治疗白塞氏葡萄膜炎的中长期结果。45例患者中,20例随访了1至4年(14例成功,5例炎症体征消退但功能无改善的满意结果,1例失败),17例随访了5至10年(9例成功,5例满意结果,3例失败),8例随访了11至16年(2例成功,2例满意结果,4例失败)。高成功率(超过55%)部分可归因于治疗开始早,部分可能归因于药物选择。

相似文献

1
[Immunosuppressive treatment of Behçet's syndrome. Long-term results].[白塞病的免疫抑制治疗。长期结果]
Ophtalmologie. 1989 Jan-Mar;3(1):40-2.
2
Long-term effects of cyclophosphamide and colchicine treatment in Behçet's disease.环磷酰胺和秋水仙碱治疗白塞病的长期疗效。
Ann Ophthalmol. 1991 Apr;23(4):148-51.
3
Treatment of severe refractory uveitis with intravenous cyclophosphamide.静脉注射环磷酰胺治疗重度难治性葡萄膜炎。
J Rheumatol. 1994 Jan;21(1):123-5.
4
Does lowering hyperhomocysteinemia by folic acid beneficial for oculo-Behcet's disease? A pilot study.叶酸降低高同型半胱氨酸血症对眼型白塞病有益吗?一项初步研究。
Tunis Med. 2007 Jun;85(6):450-3.
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Long-term progression, prognosis, and treatment of patients with recurrent ocular manifestations of Reiter's syndrome.赖特综合征复发性眼部表现患者的长期病程、预后及治疗
Ophthalmology. 2003 Sep;110(9):1764-9. doi: 10.1016/S0161-6420(03)00620-1.
6
[Value and complications of immunosuppressive therapy in uveitis of Behcet's disease or of other etiology. Apropos of 40 cases].[白塞病或其他病因性葡萄膜炎免疫抑制治疗的价值及并发症。附40例报告]
J Fr Ophtalmol. 1982;5(6-7):407-16.
7
[Cytostatic and immunosuppressive treatment of ocular Behçet syndrome].
Klin Monbl Augenheilkd. 1990 Feb;196(2):62-9. doi: 10.1055/s-2008-1046132.
8
[Bolus of cyclophosphamide and methylprednisolone in uveitis in Behçet's disease. Preliminary results with the use of new criteria of evaluation].[环磷酰胺和甲泼尼龙大剂量冲击治疗白塞病性葡萄膜炎。采用新评估标准的初步结果]
Ann Med Interne (Paris). 1992;143(7):438-41.
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Long-term results of cataract extraction with intraocular lens implantation in patients with uveitis.葡萄膜炎患者白内障摘除联合人工晶状体植入术的长期效果
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Anti-TNF-alpha therapy in seven patients with Behcet's uveitis: advantages and controversial aspects.七例白塞氏葡萄膜炎患者的抗TNF-α治疗:优势与争议点
Ann N Y Acad Sci. 2007 Sep;1110:474-84. doi: 10.1196/annals.1423.050.

引用本文的文献

1
Outcome measures used in clinical trials for Behçet syndrome: a systematic review.白塞病临床试验中使用的结局指标:一项系统评价。
J Rheumatol. 2014 Mar;41(3):599-612. doi: 10.3899/jrheum.131249. Epub 2014 Feb 1.