Niessen C, Jung E M, Beyer L, Pregler B, Dollinger M, Haimerl M, Scheer F, Stroszczynski C, Wiggermann P
Institute for Radiology, University Hospital Regensburg, Germany.
Institute of Diagnostic and Interventional Radiology, Westküstenklinikum Heide, Heide, Germany.
Clin Hemorheol Microcirc. 2015;61(2):135-41. doi: 10.3233/CH-151985.
To evaluate the use of contrast-enhanced ultrasound (CEUS) after irreversible electroporation (IRE) of prostatic cancer tissue to assess the ablation status by depicting microvascularisation in the ablation area.
Retrospective evaluation of CEUS of 13 patients (mean age: 61.4 ± 7.5 years) with histologically confirmed prostatic cancer who underwent percutaneous IRE. In the course of clinical routine, the tumor lesions were documented before, immediately after, and 1 day after the ablationusing color-coded transabdominal and transrectal CEUS. The obtained image data (DICOM loops and images) were subsequently evaluated by 2 experienced radiologists and assessed with regard to micro vascularisation by means of a 5-point scale.
CEUS images showed significantly reduced microcirculation of the lesions (mean 0.9 ± 0.6 cm (0.5-1.5 cm) after IRE. Microcirculation was reduced from 2.15 ± 0.56 prior to ablation to 0.65 ± 0.63 (p < 0.001) immediately after the ablation and to 0.27 ± 0.44 one day after IRE (p < 0.001).
This study showed rapid and significant reduction of the microcirculation in the ablation area afterpercutaneous IRE of prostatic cancer tissue.
评估在前列腺癌组织不可逆电穿孔（IRE）后使用超声造影（CEUS），通过描绘消融区域的微血管形成来评估消融状态。
对13例经组织学确诊为前列腺癌且接受经皮IRE的患者（平均年龄：61.4±7.5岁）的CEUS进行回顾性评估。在临床常规过程中，使用彩色编码经腹和经直肠CEUS在消融前、消融后即刻以及消融后1天记录肿瘤病变。随后，由2名经验丰富的放射科医生对获得的图像数据（DICOM环和图像）进行评估，并通过5分制对微血管形成进行评估。
CEUS图像显示病变的微循环显著减少（IRE后平均为0.9±0.6厘米（0.5 - 1.5厘米））。微循环从消融前的2.15±0.56降至消融后即刻的0.65±0.63（p<0.001），并在IRE后1天降至0.27±0.44（p<0.001）。
本研究表明，前列腺癌组织经皮IRE后，消融区域的微循环迅速且显著减少。
