盐酸脒与甲基芳烃的直接氧化偶联：无金属条件下叔丁基过氧化氢介导的取代1,3,5-三嗪的合成。
Direct oxidative coupling of amidine hydrochlorides and methylarenes: TBHP-mediated synthesis of substituted 1,3,5-triazines under metal-free conditions.
作者信息
Guo Wei
机构信息
School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510641, People's Republic of China.
出版信息
Org Biomol Chem. 2015 Nov 7;13(41):10285-9. doi: 10.1039/c5ob01799h.
PMID:26411699
Abstract
Various 2,4,6-trisubstituted 1,3,5-triazines were smoothly formed via TBHP-mediated direct oxidative coupling of amidine and methylarenes. This tandem oxidation-imination-cyclization transformation exhibits a straightforward protocol to prepare 1,3,5-triazines from easily available starting materials and green oxidants under metal-free conditions.
摘要
通过叔丁基过氧化氢（TBHP）介导的脒与甲基芳烃的直接氧化偶联反应，顺利地生成了各种2,4,6-三取代的1,3,5-三嗪。这种串联氧化-亚胺化-环化转化反应展示了一种在无金属条件下，从易于获得的起始原料和绿色氧化剂制备1,3,5-三嗪的直接方法。
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