Elgaml Abdelaziz, Miyoshi Shin-Ichi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.
Biocontrol Sci. 2015;20(3):199-203. doi: 10.4265/bio.20.199.
Vibrio vulnificus is a halophilic estuarine bacterium, but this species causes fatal septicemia in humans. V. vulnificus may encounter many kinds of stresses either in the natural environment or in the human body. One of the striking stresses is the exposure to the reactive oxygen species including nitric oxide (NO). The present study revealed that NO could participate in the regulation of the V. vulnificus community behavior. When the bacterium was cultivated in the presence of sub-lethal doses of an NO donor, the expression of the genes encoding NO-detoxifying enzymes was significantly increased. The NO donor was also found to cause significant increase in production of a metalloprotease, a putative virulence factor, by the bacterium.
创伤弧菌是一种嗜盐性河口细菌，但该菌种会在人类中引发致命的败血症。创伤弧菌在自然环境或人体中可能会遭遇多种应激。其中一种显著的应激是暴露于包括一氧化氮（NO）在内的活性氧物种。本研究表明，NO可参与创伤弧菌群体行为的调控。当该细菌在亚致死剂量的NO供体存在下培养时，编码NO解毒酶的基因表达显著增加。还发现NO供体可导致该细菌产生一种金属蛋白酶（一种假定的毒力因子）的量显著增加。
