Saito Mitsuru, Marumo Keishi
Department of Orthopaedic Surgery, Jikei University School of Medicine, Tokyo, Japan.
Clin Calcium. 2015 Oct;25(10):1541-54.
Active vitamin D3 is used for the treatment for osteoporosis in Japan. Recently, data have accumulated that collagen cross-link formation in bone affect bone strength. In fact, impaired enzymatic cross-linking, over-hydroxylation of crosslinks, and an increase in non-enzymatic crosslinking advanced glycation end products (AGEs) such as pentosidine, in bone collagen have been proposed as a major cause of bone fragility in osteoporosis. We reported that alfacalcidol and eldecalcitol improves bone material properties such as collagen cross-link formation, microarchitecture, and microcrack resulting in the increase of bone strength (Saito M, Bone 2010;46:1170-1179, Calcif Tissue Int 2011;88:314-324, Bone, 2015;73:8-15). In this review, we described how active vitamin D3 improve bone collagen cross-link formation and mineral qualities.
活性维生素D3在日本被用于治疗骨质疏松症。最近，越来越多的数据表明，骨骼中的胶原蛋白交联形成会影响骨强度。事实上，骨胶原蛋白中酶促交联受损、交联过度羟化以及非酶促交联晚期糖基化终产物（如戊糖苷）增加，已被认为是骨质疏松症中骨脆性的主要原因。我们报道，阿法骨化醇和依地骨化醇可改善骨材料特性，如胶原蛋白交联形成、微观结构和微裂纹，从而提高骨强度（斋藤M，《骨》2010年；46:1170 - 1179，《钙化组织国际》2011年；88:314 - 324，《骨》，2015年；73:8 - 15）。在这篇综述中，我们描述了活性维生素D3如何改善骨胶原蛋白交联形成和矿物质质量。
