Weinerman Stuart, Usera Gianina L
Division of Endocrinology & Diabetes, Department of Medicine, Hofstra North Shore-LIJ School of Medicine, 865 Northern Boulevard, Suite 203, Great Neck, New York 11021, USA.
Division of Endocrinology & Diabetes, Department of Medicine, Hofstra North Shore-LIJ School of Medicine, 865 Northern Boulevard, Suite 203, Great Neck, New York 11021, USA.
Oral Maxillofac Surg Clin North Am. 2015 Nov;27(4):555-60. doi: 10.1016/j.coms.2015.07.001. Epub 2015 Sep 26.
Osteoporosis is a disease of low bone density, translating to increased fragility and risk for fracture. It is a significant public health problem that is widely undertreated, despite the many options of treatment available. Among these, the most effective are the antiresorptive medications, such as bisphosphonates. There is an abundance of evidence about the efficacy and safety profile of these medications. However, there is mounting evidence that, after 10 years on treatment with a bisphosphonate, patients are at a higher risk of developing some of the serious side effects of atypical femur fractures and osteonecrosis of the jaw.
骨质疏松症是一种骨密度低的疾病，这意味着骨骼脆性增加和骨折风险升高。它是一个重大的公共卫生问题，尽管有多种可用的治疗选择，但仍普遍存在治疗不足的情况。其中，最有效的是抗吸收药物，如双膦酸盐类药物。关于这些药物的疗效和安全性有大量证据。然而，越来越多的证据表明，在用双膦酸盐治疗10年后，患者发生非典型股骨骨折和颌骨坏死等一些严重副作用的风险更高。
