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用于治疗勃起功能障碍和良性前列腺增生继发下尿路症状的5型磷酸二酯酶抑制剂：一项综述

Phosphodiesterase type 5 inhibitors for treating erectile dysfunction and lower urinary tract symptoms secondary to benign prostatic hyperplasia: A comprehensive review.

作者信息

Haddad Albert, Jabbour Michel, Bulbul Muhammad

机构信息

Lilly Research Laboratories, Eli Lilly and Company, Dubai, United Arab Emirates.

Division of Urology, Saint Georges Hospital, Balamand University, Achrafieh, Beirut, Lebanon.

出版信息

Arab J Urol. 2015 Sep;13(3):155-61. doi: 10.1016/j.aju.2015.06.004. Epub 2015 Jul 10.

DOI:10.1016/j.aju.2015.06.004
PMID:26413339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4563010/
Abstract

Many men have coexistent erectile dysfunction (ED) and lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH). Phosphodiesterase type 5 (PDE5) inhibitors are effective for treating both of these conditions independently. In this review we summarise the evidence supporting a link between ED and LUTS/BPH, and the results from key clinical studies related to the use of PDE5 inhibitors for treating both conditions. The results from these studies suggest that men who have both ED and LUTS/BPH, and are concerned about their sexual dysfunction, might benefit from single-agent, holistic treatment with a PDE5 inhibitor.

摘要

许多男性同时存在勃起功能障碍（ED）以及继发于良性前列腺增生的下尿路症状（LUTS/BPH）。5型磷酸二酯酶（PDE5）抑制剂可分别有效治疗这两种病症。在本综述中，我们总结了支持ED与LUTS/BPH之间存在关联的证据，以及与使用PDE5抑制剂治疗这两种病症相关的关键临床研究结果。这些研究结果表明，同时患有ED和LUTS/BPH且担心其性功能障碍的男性，可能会从使用PDE5抑制剂进行单药整体治疗中获益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79e5/4563010/f08815e6547c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79e5/4563010/f08815e6547c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79e5/4563010/f08815e6547c/gr1.jpg

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Efficacy and safety of the coadministration of tadalafil once daily with finasteride for 6 months in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia.每日一次他达拉非联合非那雄胺治疗良性前列腺增生所致下尿路症状和前列腺增生的 6 个月疗效和安全性。
J Urol. 2014 Mar;191(3):727-33. doi: 10.1016/j.juro.2013.09.059. Epub 2013 Oct 2.
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Innovative trends and perspectives for erectile dysfunction treatment: A systematic review.
勃起功能障碍治疗的创新趋势与展望：一项系统综述。
Arab J Urol. 2016 May 18;14(2):84-93. doi: 10.1016/j.aju.2016.04.002. eCollection 2016 Jun.
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New therapeutic strategies for the treatment of male lower urinary tract symptoms.治疗男性下尿路症状的新治疗策略。
Res Rep Urol. 2016 Apr 26;8:51-9. doi: 10.2147/RRU.S63446. eCollection 2016.
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BJU Int. 2013 Nov;112(7):990-7. doi: 10.1111/bju.12251. Epub 2013 Aug 13.
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