Özdemir Bülent, Emül Ali, Özdemir Levent, Sağ Saim, Biçer Murat, Aydınlar Ali
Department of Cardiology, Uludağ University, Bursa, Turkey.
Şevket Yılmaz Government Research and Training Hospital, Bursa, Turkey.
Biomed Res Int. 2015;2015:857628. doi: 10.1155/2015/857628. Epub 2015 Aug 27.
Aortic diameters, aortic distensibility, microalbuminuria, coronary artery disease which are all together related to vascular aging are investigated in this paper.
Eighty consecutive nondiabetic patients undergoing elective coronary angiography were enrolled into the study. Systolic and diastolic aortic diameters, aortic distensibility, CAD severity by angiogram with the use of Gensini scoring, and albumin excretion rates were determined.
Cases with CAD had significantly larger systolic (30,72 ± 3,21 mm versus 34,19 ± 4,03 mm for cases without and with CAD, resp.) and diastolic aortic diameters measured 3 cm above aortic valve compared to patients without CAD (33,56 ± 4,07 mm versus 29,75 ± 3,12 mm). The systolic and diastolic diameters were significantly higher in albuminuria positive patients compared to albuminuria negative patients (p = 0.017 and 0.008, resp., for systolic and diastolic diameters).
In conclusion aortic diameters are increased in patients with coronary artery disease and in patients with microalbuminuria. In CAD patients, systolic blood pressure, pulse pressure, aortic systolic and diastolic pressure, and albumin excretion rate were higher and aortic distensibility was lower.
本文研究了与血管老化相关的主动脉直径、主动脉扩张性、微量白蛋白尿和冠状动脉疾病。
连续纳入80例接受择期冠状动脉造影的非糖尿病患者。测定收缩期和舒张期主动脉直径、主动脉扩张性、使用Gensini评分通过血管造影评估的CAD严重程度以及白蛋白排泄率。
与无CAD的患者相比，CAD患者在主动脉瓣上方3 cm处测量的收缩期主动脉直径（无CAD和有CAD的患者分别为30.72±3.21 mm和34.19±4.03 mm）和舒张期主动脉直径显著更大（分别为33.56±4.07 mm和29.75±3.12 mm）。与微量白蛋白尿阴性患者相比，微量白蛋白尿阳性患者的收缩期和舒张期直径显著更高（收缩期和舒张期直径的p值分别为0.017和0.008）。
总之，冠状动脉疾病患者和微量白蛋白尿患者的主动脉直径增加。在CAD患者中，收缩压、脉压、主动脉收缩压和舒张压以及白蛋白排泄率更高，而主动脉扩张性更低。
