大鼠中与性别相关的canatoxin诱导的血糖变化。

Sex-related canatoxin-induced blood glucose alterations in the rat.

Pires-Barbosa R, Ribeiro-DaSilva G

Departamento de Farmacologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Brasil.

Braz J Med Biol Res. 1989;22(12):1507-13.

Abstract

The present study was designed to characterize sex-related canatoxin-induced blood glucose alterations in rats. 2. Chronic administration of canatoxin (50 mU, ip, daily for 3 days) induced hypoglycemia in female rats (N = 6) (-36.54 +/- 3.24%, P less than 0.05). The response of pregnant rats (N = 8) was similar to that observed for male rats (+29.57 +/- 4.70%). 3. Administration of canatoxin did not modify blood glucose levels of gonadectomized male or female rats. Similarly, pretreatment of intact male or female rats with human chorionic gonadotropin (40 IU/kg, im) blocked the effect of canatoxin on blood glucose levels. 4. Gonadal steroid replacement (testosterone, 10 mg/kg, im) for gonadectomized male rats did not reverse the inhibition of canatoxin-induced blood glucose alterations, whereas pretreatment of intact female rats (N = 6) with testosterone (10 mg/kg, im) significantly attenuated the canatoxin-induced hypoglycemia. 5. These data indicate that the blood glucose alterations produced by canatoxin in rats are under hormonal regulation.

摘要

本研究旨在表征大鼠中与性别相关的卡纳毒素诱导的血糖变化。2. 慢性给予卡纳毒素（50 mU，腹腔注射，每日一次，共3天）可诱导雌性大鼠（N = 6）出现低血糖（-36.54 +/- 3.24%，P < 0.05）。怀孕大鼠（N = 8）的反应与雄性大鼠相似（+29.57 +/- 4.70%）。3. 给予卡纳毒素不会改变去势雄性或雌性大鼠的血糖水平。同样，用人类绒毛膜促性腺激素（40 IU/kg，肌肉注射）对完整雄性或雌性大鼠进行预处理可阻断卡纳毒素对血糖水平的影响。4. 对去势雄性大鼠进行性腺类固醇替代（睾酮，10 mg/kg，肌肉注射）并不能逆转卡纳毒素诱导的血糖变化的抑制作用，而用睾酮（10 mg/kg，肌肉注射）对完整雌性大鼠（N = 6）进行预处理可显著减轻卡纳毒素诱导的低血糖。5. 这些数据表明，卡纳毒素在大鼠中产生的血糖变化受激素调节。