Gleason Brigette, Mirembe Grace, Namuyonga Judith, Okello Emmy, Lwabi Peter, Lubega Irene, Lubega Sulaiman, Musiime Victor, Kityo Cissy, Salata Robert A, Longenecker Chris T
*Case Western Reserve University School of Medicine, Cleveland, OH; †University Hospitals Case Medical Center, Cleveland, OH; ‡Joint Clinical Research Center, Kampala, Uganda; §Makerere University School of Medicine, Kampala, Uganda; and ‖Uganda Heart Institute, Kampala, Uganda.
J Acquir Immune Defic Syndr. 2016 Feb 1;71(2):196-9. doi: 10.1097/QAI.0000000000000827.
Rheumatic heart disease (RHD) remains highly prevalent in resource-constrained settings around the world, including countries with high rates of HIV/AIDS. Although both are immune-mediated diseases, it is unknown whether HIV modifies the risk or progression of RHD. We performed screening echocardiography to determine the prevalence of latent RHD in 488 HIV-infected children aged 5-18 in Kampala, Uganda. The overall prevalence of borderline/definite RHD was 0.82% (95% confidence interval: 0.26% to 2.23%), which is lower than the published prevalence rates of 1.5%-4% among Ugandan children. There may be protective factors that decrease the risk of RHD in HIV-infected children.
风湿性心脏病（RHD）在包括艾滋病病毒/艾滋病高发国家在内的全球资源有限地区仍然非常普遍。尽管两者都是免疫介导的疾病，但尚不清楚艾滋病病毒是否会改变风湿性心脏病的风险或病程。我们进行了超声心动图筛查，以确定乌干达坎帕拉488名5至18岁感染艾滋病病毒儿童中潜在风湿性心脏病的患病率。临界/确诊风湿性心脏病的总体患病率为0.82%（95%置信区间：0.26%至2.23%），低于乌干达儿童公布的1.5%-4%的患病率。可能存在一些保护因素可降低感染艾滋病病毒儿童患风湿性心脏病的风险。
