Karam Irene, Poon Ian, Lee Justin, Liu Stanley, Higgins Kevin, Enepekides Danny, Sahgal Arjun, Lo Simon S
Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Science Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
Department of Otolaryngology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
Future Oncol. 2015;11(21):2937-47. doi: 10.2217/fon.15.236. Epub 2015 Sep 28.
In the recent years, stereotactic body radiation therapy (SBRT) has emerged as a potential therapy for head and neck malignancies. Although early results appear to be promising, serious acute and late effects have been observed, mainly in patients who have had prior external beam radiotherapy. This review will discuss the radiobiology of SBRT, clinical rationale and outcomes for SBRT in head and neck cancers and focus on the benefits and potential limitations in both de novo and re-irradiation settings.
近年来，立体定向体部放射治疗（SBRT）已成为头颈部恶性肿瘤的一种潜在治疗方法。尽管早期结果似乎很有前景，但已观察到严重的急性和晚期效应，主要出现在既往接受过外照射放疗的患者中。本综述将讨论SBRT的放射生物学、SBRT用于头颈部癌症的临床原理和结果，并重点关注初治和再程放疗情况下的益处及潜在局限性。
