Gomez-Gelvez Juan C, Smith Lauren B
From the Department of Pathology, University of Michigan Medical School, Ann Arbor.
Arch Pathol Lab Med. 2015 Oct;139(10):1205-10. doi: 10.5858/arpa.2015-0197-RAI.
Large atypical cells with morphologic and immunophenotypic features resembling Reed-Sternberg cells can be seen in the background of reactive lymphadenopathies as well as non-Hodgkin lymphomas. The presence of these cells is an important diagnostic pitfall that must be recognized by pathologists who regularly interpret lymph node biopsies. A thorough evaluation of the morphologic and immunophenotypic features of these cells and the cellular milieu is crucial in achieving the correct diagnosis. In this review, examples of lymphomas presenting with Reed-Sternberg-like cells will be provided. Additionally, a detailed description of the common morphologic and immunophenotypic features of these cells, as well as strategies that can be used to distinguish them from the Reed-Sternberg cells of classical Hodgkin lymphoma, will be emphasized.
在反应性淋巴结病以及非霍奇金淋巴瘤的背景中，可见具有类似于里德-斯腾伯格细胞形态学和免疫表型特征的大非典型细胞。这些细胞的存在是一个重要的诊断陷阱，经常解读淋巴结活检的病理学家必须认识到这一点。对这些细胞的形态学和免疫表型特征以及细胞环境进行全面评估对于做出正确诊断至关重要。在本综述中，将提供出现里德-斯腾伯格样细胞的淋巴瘤实例。此外，将重点详细描述这些细胞的常见形态学和免疫表型特征，以及可用于将它们与经典霍奇金淋巴瘤的里德-斯腾伯格细胞区分开来的策略。
