School of Chemistry and Chemical Engineering, Shaanxi Normal University , No.620 West Chang'an Avenue, Xi'an 710119, China.
Org Lett. 2015 Oct 16;17(20):5124-7. doi: 10.1021/acs.orglett.5b02663. Epub 2015 Sep 28.
A gold(I)-catalyzed formal [4 + 1] cycloaddition of α-diazoesters and propargyl alcohols is disclosed, offering access to a variety of 2,5-dihydrofurans. The reaction shows a broad substrate scope and functional group tolerance. Preliminary mechanistic investigation indicates that this reaction most likely occurs through a 5-endo-dig cyclization of an α-hydroxy allene intermediate.
公开了一种金（I）催化的α-重氮酯和炔丙醇的[4 + 1]环加成反应，为多种 2,5-二氢呋喃的合成提供了途径。该反应具有广泛的底物范围和官能团容忍性。初步的机理研究表明，该反应很可能是通过α-羟丙炔中间体的 5-endo-环化来进行的。
