Alghamdi Faisal, Morais Ricardo, Scillia Pietro, Lubicz Boris
a 1 Department of Neuroradiology, Erasme University Hospital , Hôpital Erasme, 808 route de Lennik, 1070 Bruxelles, Belgium.
b 2 Department of Radiology, Erasme University Hospital , Brussels 1070, Belgium.
Expert Rev Med Devices. 2015;12(6):753-62. doi: 10.1586/17434440.2015.1093413. Epub 2015 Sep 28.
Flow diverter (FD) stents represent a new endovascular technique developed for the treatment of complex intracranial aneurysms (wide neck, fusiform, large, and giant aneurysms) that are challenging for classic endovascular techniques such as coiling, balloon-assisted coiling and stent-assisted coiling. Low porosity, high metal coverage, and high pore density are the main properties of FD stents. These properties induce hemodynamic changes redirecting the blood flow away from the aneurysm and into the parent artery leading to gradual thrombosis of the aneurysm. FD stents also provide scaffolding for subsequent neoendothelial proliferation, and vessel wall remodeling. This is considered as a paradigm shift compared to prior endovascular methods, which predominantly aimed at providing treatment inside the aneurysmal sac. This paper describes in detail the first released FD stent, the Silk flow-diverter stent (Balt Extrusion, Montmorency, France), its mechanism of action and deployment technique. It reviews the pertinent literature regarding safety, efficacy and potential risks and complications associated with the use of this stent.
血流导向(FD)支架代表了一种新的血管内治疗技术,用于治疗复杂颅内动脉瘤(宽颈、梭形、大型和巨大动脉瘤),这些动脉瘤对于传统血管内技术(如弹簧圈栓塞、球囊辅助弹簧圈栓塞和支架辅助弹簧圈栓塞)来说具有挑战性。低孔隙率、高金属覆盖率和高孔隙密度是FD支架的主要特性。这些特性会引起血流动力学变化,使血流从动脉瘤转向流入载瘤动脉,从而导致动脉瘤逐渐血栓形成。FD支架还为后续的新生内皮细胞增殖和血管壁重塑提供支架。与以往主要旨在在动脉瘤腔内进行治疗的血管内方法相比,这被认为是一种范式转变。本文详细描述了首个获批的FD支架——Silk血流导向支架(法国蒙特莫朗西的巴尔特种挤压公司),其作用机制和植入技术。本文回顾了有关该支架使用的安全性、有效性以及潜在风险和并发症的相关文献。