Błasiak M, Kuska J, Kokot F, Irzyniec T
Endokrynol Pol. 1989;40(5):251-62.
The changes in blood serum concentrations of calcium, magnesium, inorganic phosphate, total activity of alkaline phosphatase and the activity of its bone fraction, as well as urinary excretion of calcium, phosphate, hydroxyproline and oxalate have been measured in 31 patients with insulin-dependent (type I) diabetes, in 31 patients with non-insulin-dependent (type II) diabetes and in 29 healthy subjects in the condition of low-calcium diet. The elevated urinary excretion of calcium, phosphate, hydroxyproline and oxalate, lowered blood serum level of magnesium, and increased total and bone fraction activities of alkaline phosphatase were found in diabetic patients. The urinary excretion of calcium and hydroxyproline, and the activity of bone fraction alkaline phosphatase were significantly higher in patients with type II diabetes than in those with type I diabetes. It was concluded that there is a significant relation between the state of metabolic normalization of diabetes and the degree of biochemical aberrations concerning calcium-phosphate metabolism.
对31例胰岛素依赖型（I型）糖尿病患者、31例非胰岛素依赖型（II型）糖尿病患者和29名健康受试者在低钙饮食条件下，测定了血清钙、镁、无机磷、碱性磷酸酶总活性及其骨部分活性，以及尿钙、磷、羟脯氨酸和草酸盐的排泄情况。糖尿病患者尿钙、磷、羟脯氨酸和草酸盐排泄增加，血清镁水平降低，碱性磷酸酶总活性和骨部分活性增加。II型糖尿病患者尿钙和羟脯氨酸排泄量以及骨部分碱性磷酸酶活性显著高于I型糖尿病患者。得出结论：糖尿病代谢正常化状态与钙磷代谢生化异常程度之间存在显著关系。
