水毒芹（Cicuta douglasii）块茎的水提取物对GABAA受体的非竞争性阻断作用。

The non-competitive blockade of GABAA receptors by an aqueous extract of water hemlock (Cicuta douglasii) tubers.

作者信息

Green Benedict T, Goulart Camila, Welch Kevin D, Pfister James A, McCollum Isabelle, Gardner Dale R

机构信息

Poisonous Plant Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Logan, UT, USA.

Graduate Program in Animal Science, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.

出版信息

Toxicon. 2015 Dec 15;108:11-4. doi: 10.1016/j.toxicon.2015.09.015. Epub 2015 Sep 28.

DOI:10.1016/j.toxicon.2015.09.015

PMID:26415905

Abstract

Water hemlocks (Cicuta spp.) are acutely toxic members of the Umbellierae family; the toxicity is due to the presence of C17-polyacetylenes such as cicutoxin. There is only limited evidence of noncompetitive antagonism by C17-polyacetylenes at GABAA receptors. In this work with WSS-1 cells, we documented the noncompetitive blockade of GABAA receptors by an aqueous extract of water hemlock (Cicuta douglasii) and modulated the actions of the extract with a pretreatment of 10 μM midazolam.

摘要

水毒芹（毒芹属）是伞形科剧毒植物；其毒性归因于C17 - 聚乙炔类物质的存在，如水毒芹毒素。关于C17 - 聚乙炔类物质在GABAA受体上的非竞争性拮抗作用，仅有有限的证据。在这项针对WSS - 1细胞的研究中，我们记录了水毒芹（道格拉斯毒芹）水提取物对GABAA受体的非竞争性阻断作用，并通过10 μM咪达唑仑预处理来调节该提取物的作用。