肝脂肪变性与转移性乳腺癌患者肝转移的较高发生率相关；一项观察性临床研究。
Hepatic steatosis is associated with higher incidence of liver metastasis in patients with metastatic breast cancer; an observational clinical study.
作者信息
Ocak Duran Ayse, Yildirim Afra, Inanc Mevlude, Karaca Halit, Berk Veli, Bozkurt Oktay, Ozaslan Ersin, Ucar Mahmut, Ozkan Metin
机构信息
1Department of Medical Oncology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
出版信息
J BUON. 2015 Jul-Aug;20(4):963-9.
PURPOSE
To investigate the relationship between hepatic steatosis (HS) (at the time of diagnosis) and hepatic metastasis (at the time of diagnosis and follow-up) in metastatic breast cancer (BC) patients by using computed tomography (CT).
METHODS
A total of 107 metastatic BC patients who had an abdominal CT were retrospectively enrolled in this study. Patients without HS (N=79) were regarded as the control group and those with HS constituted the HS study group (N-28).
RESULTS
Hepatic metastases at diagnosis and during follow-up were more common in patients with HS (p=0.018 and p=0.041, respectively) and in the premenopausal group (p<0.001 and p=0.004, respectively), whereas they were similar in patients with and without HS in the postmenopausal group (p=0.655 and p=0.656, respectively). Overall survival rates were similar in patients with and without HS (p=0.606).
CONCLUSION
Hepatic metastases at diagnosis and during follow-up were more frequent in patients with HS, especially in premenopausal patients. Survival was similar in both groups.
目的
通过计算机断层扫描（CT）研究转移性乳腺癌（BC）患者诊断时的肝脂肪变性（HS）与诊断及随访时肝转移之间的关系。
方法
本研究回顾性纳入了107例行腹部CT检查的转移性BC患者。无HS的患者（N = 79）被视为对照组，有HS的患者构成HS研究组（N = 28）。
结果
诊断时及随访期间肝转移在有HS的患者中更常见（分别为p = 0.018和p = 0.041），在绝经前组中也更常见（分别为p < 0.001和p = 0.004），而在绝经后组中有HS和无HS的患者中肝转移情况相似（分别为p = 0.655和p = 0.656）。有HS和无HS的患者总生存率相似（p = 0.606）。
结论
诊断时及随访期间肝转移在有HS的患者中更频繁，尤其是绝经前患者。两组生存率相似。
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