脾照射作为继发于骨髓纤维化的有症状脾肿大的姑息治疗：多机构经验

Splenic irradiation as palliative treatment for symptomatic splenomegaly due to secondary myelofibrosis: a multi-institutional experience.

作者信息

Pistevou-Gombaki Kiki, Zygogianni Anna, Kantzou Ioanna, Kyrgias George, Mystakidou Kyriaki, Kouvaris John, Klonizakis Ioannis, Tsirigotis Panagiotis, Pappa Vassiliki, Siakantari Marina, Eleftheriadis Nikos, Georgakopoulos John, Sarris George, Kelekis Nikolaos, Kouloulias Vassilios

机构信息

Department of Radiation Oncology, AHEPA Hospital, Aristoteles University of Thessaloniki, Thessaloniki, Greece.

出版信息

J BUON. 2015 Jul-Aug;20(4):1132-6.

PMID:26416067

Abstract

PURPOSE

To evaluate the impact of splenic irradiation as a palliative treatment for symptomatic splenomegaly due to secondary myelofibrosis.

METHODS

Seventeen patients with chronic myelogenous leukemia and 3 with idiopathic polycythaemia presented with splenomegaly, splenic pain and anemia. Due to symptomatic splenomegaly, despite first-line treatment, the patients underwent splenic irradiation. Two patients received two different schedules of external radiotherapy (580 cGy in 5 fractions and 600 cGy in 6 fractions). Eight patients received 980 cGy in 14 fractions. Ten patients received two courses of 360 cGy in 6 fractions, 3 months apart. Median follow-up was 12 months post irradiation.

RESULTS

The patients showed excellent response to treatment one month post-radiotherapy, while treatment was well tolerated without severe toxicity. The dimensions of the spleen decreased significantly. Pain-related Visual Analogue Score (VAS) regressed after completion of irradiation. During 12-month follow-up all patients maintained the benefit of radiotherapy.

CONCLUSION

This study indicates that splenic irradiation could be a safe and effective palliative treatment for symptomatic splenomegaly due to secondary myelofibrosis.

摘要

目的

评估脾区照射作为继发于骨髓纤维化的有症状脾肿大的姑息治疗的效果。

方法

17例慢性粒细胞白血病患者和3例真性红细胞增多症患者出现脾肿大、脾区疼痛和贫血。尽管进行了一线治疗，但由于有症状的脾肿大，这些患者接受了脾区照射。2例患者接受了两种不同方案的外照射放疗（5次分割共580 cGy和6次分割共600 cGy）。8例患者接受了14次分割共980 cGy的照射。10例患者接受了两个疗程、每次6次分割共360 cGy、间隔3个月的照射。放疗后中位随访时间为12个月。