Bucher Joshua, Koyfman Alex
Rutgers - Robert Wood Johnson Medical School, Piscataway, New Jersey.
University of Texas Southwestern Medical Center, Dallas, Texas.
J Emerg Med. 2015 Dec;49(6):920-7. doi: 10.1016/j.jemermed.2015.06.078. Epub 2015 Sep 26.
Intubation of the neurologically injured patient is a critical procedure that must be done in a manner to prevent further neurologic injury. Although many different medications and techniques have been used to meet specific needs, there is little to no evidence to support many claims.
To review the literature regarding important topics relating to intubating patients with neurologic injury.
Airway management requires ideal preoxygenation and airway maneuvers to minimize manipulation of the larynx and to maximize first-pass success. There is no evidence that lidocaine pretreatment decreases intracerebral pressure (ICP). Fentanyl can be used to help blunt the hemodynamic response to intubation. Esmolol is another medication that can blunt the hemodynamic response. Ketamine can be used and is possibly the ideal agent, having a neutral hemodynamic profile. A prefasciculation dose for neuromuscular blockade has not been shown to have any effect on ICP.
Ideal intubation conditions should be obtained through the use of airway manipulation techniques and appropriate medication choice for rapid sequence intubation in patients who are neurologically injured.
对神经损伤患者进行插管是一项关键操作,必须以防止进一步神经损伤的方式进行。尽管已使用许多不同的药物和技术来满足特定需求,但几乎没有证据支持许多说法。
回顾有关神经损伤患者插管相关重要主题的文献。
气道管理需要理想的预充氧和气道操作,以尽量减少对喉部的操作并最大化首次插管成功率。没有证据表明利多卡因预处理可降低颅内压(ICP)。芬太尼可用于帮助减轻插管引起的血流动力学反应。艾司洛尔是另一种可减轻血流动力学反应的药物。氯胺酮可以使用,并且可能是理想的药物,具有中性的血流动力学特征。尚未证明神经肌肉阻滞的预肌松剂量对颅内压有任何影响。
对于神经损伤患者,应通过使用气道操作技术和选择合适的药物进行快速顺序插管,以获得理想的插管条件。